Regarding the potassium issue, I've found that needing an extra 2000mg per day is a continual part of taking even a very small amount of methyl b12. Up to quite high dose I've found this need doesn't vary and is easy to keep under control with supplements. Experimenting with high doses of enzymatic therapy, in the range of 30mg, has created a more voracious need for potassium that is over 5000mg per day and harder toi keep under control. This requires complete salt avoidance and supplementaion through the day and waking in the night. So quite difficult. I'm not certain how the folate and b vamins are playing into this, to be determined by observation. I've backed down to alternating between 15mg of enzymatic therapy and 60mg AOR mb12s.