This thread is about ME/CFS patients who feel too mentally frail to engage socially. I am not talking about the state of being too tired, or being too brain fogged to engage socially; I am talking about the state where your "mental backbone" feels too weak to want take part in any human interactions. In this state of weak "mental backbone", you feel kind of unsure about who your are, you feel uneasy about offering any of your thoughts or opinions to others, feel very uneasy about presenting yourself to others or extending yourself to others, and feel uncomfortable in expressing your personality to others. In this frail state, you feel you don't want to engage or interact with the world, in case there is some comeback. You only feel comfortable in interacting with the world if you can do so at a distance, such that your are insulated from any results. Thus for example, you feel much more comfortable interacting anonymously online, where you are distanced from the world, and can run away from the interaction at any time just by getting up from your computer. In this frail state, it feels that your strength of mind has gone, and you become feeble emotionally. It is the very opposite of character and charisma. Of course you can use willpower and determination to try to cope with this frail mental disposition when you have to socialize and interact with people, and you may do this successfully, such that people don't even notice that there is anything wrong; but this does not diminish the fact that internally you are suffering from this frail mental state. I wish I knew the correct psychological technical term for this frail condition of mind, but I don't, so I am trying my best to describe the condition. Perhaps some of the psychologists here might be able to put a name to these mental symptoms — symptoms which I suspect are common in a substantial number of ME/CFS patients. Before I go on, let me say that although I suffered from this frail mental state for several years, I discovered that very low doses of the drug amisulpride work wonders in vanquishing these symptoms of mental frailty. So fortunately, for me most of the old character and charisma is back. The main purpose of this thread is to pass on this information: that amisulpride in very low doses of 12.5 to 25 mg daily can abolish most of these symptoms of a frail "mental backbone". Amisulpride is generally useful for ME/CFS, and a thread on the general benefits of this drug for ME/CFS can be found here. I was only reminded of this frail mental state as I decided to take a break from amisulpride for a few days, and very soon I felt this mental frailty return to a degree. But within hours of taking some amisulpride, the mental frailty disappeared. So amisulpride does seem to be an effective treatment for mental frailty. Note that amisulpride is not yet licensed in the US, but is available in Europe. Anyone can of course buy this drug from overseas pharmacies such as this one.