New Atmosphere, New Vision: Gibson and Whittemore Kick Off Invest in ME Conference 2016
Mark Berry reports on Dr. Gibson's introduction and Dr. Whittemore's keynote speech, at the 11th Invest in ME International ME Conference in London.
Discuss the article on the Forums.

Relevant to PEM - excercise and serotonin metabolism

Discussion in 'Other Health News and Research' started by natasa778, Jun 7, 2013.

  1. natasa778

    natasa778 Senior Member

    Messages:
    1,736
    Likes:
    2,185
    apologies if this has been discussed before ... there are several threads on inflammation and serotonin metabolism and related issues so wasn't sure where to post.

    btw indoleamine 2,3-dioxygenase (IDO) is already overexpressed in chronic infectious/inflammatory states (via interferon), so most likely implicated in ME. Wondering what happens in the scenario above in cases where this pathway is already dysfunctional or stressed or somehow blocked?

    So instead of more energy (NAD) following excercise because of this blockage/dysfunction in the pathway we get more toxic metabolites of that pathway - kynurenic and quinolinic acids??


    For the brave :) http://en.wikipedia.org/wiki/File:KP_pathway.jpg
     
  2. Bob

    Bob

    Messages:
    12,423
    Likes:
    37,294
    England (south coast)
  3. xchocoholic

    xchocoholic Senior Member

    Messages:
    2,947
    Likes:
    1,676
    Florida
    If I read this correctly, we finally know why rats get depressed after running on treadmills. :nerd:
     
    Bob and Valentijn like this.

See more popular forum discussions.

Share This Page