Home care is the theme for Severe ME Day on August 8th
Why should home care be the theme on Understanding and Remembrance Day for Severe ME on August 8? Helen Brownlie of the 25% ME Group has written an explanation for Phoenix Rising ...
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Relevant to PEM - excercise and serotonin metabolism

Discussion in 'Other Health News and Research' started by natasa778, Jun 7, 2013.

  1. natasa778

    natasa778 Senior Member

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    apologies if this has been discussed before ... there are several threads on inflammation and serotonin metabolism and related issues so wasn't sure where to post.

    btw indoleamine 2,3-dioxygenase (IDO) is already overexpressed in chronic infectious/inflammatory states (via interferon), so most likely implicated in ME. Wondering what happens in the scenario above in cases where this pathway is already dysfunctional or stressed or somehow blocked?

    So instead of more energy (NAD) following excercise because of this blockage/dysfunction in the pathway we get more toxic metabolites of that pathway - kynurenic and quinolinic acids??


    For the brave :) http://en.wikipedia.org/wiki/File:KP_pathway.jpg
     
  2. Bob

    Bob

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    England (south coast)
  3. xchocoholic

    xchocoholic Senior Member

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    If I read this correctly, we finally know why rats get depressed after running on treadmills. :nerd:
     
    Bob and Valentijn like this.

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