1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Give ME the Money
Graham McPhee spells out some of the cold, hard facts about the dismal state of ME research and politics, and has some suggestions as to what we can do about it ...
Discuss the article on the Forums.

Relationship between B12 and Folates

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by R++, Apr 16, 2010.

  1. Lotus97

    Lotus97 Senior Member

    Messages:
    2,015
    Likes:
    423
    United States
    If hydroxocobalamin converts to methylcobalamin would too much of hydroxy b12 also cause problems with mercury? Also, is it possible that it wasn't the methylcobalamin that directly mobilized the mercury, but rather the methylation process itself that was responsible? Maybe since methylcobalamin is the most potent type of B12 for jumpstarting methylation it is the most likely to do so.
     
  2. Freddd

    Freddd Senior Member

    Messages:
    4,582
    Likes:
    958
    Salt Lake City
    MeCbl and l-metjhylfolate will start the first of 6 levels of healing almost 100% of time, about 20% of time requiring AdoCbl and L-carnitine fumarate, becasue these are all mutually deadlocking functionally. I almost have a complete explanation worked up that will be posted soon. Also, as Carmen Wheatley's paper, LARGE GORILLA ... ADENOSYLCOBALAMIN... said, HyCbl appears to be a workaround to a starvation situation allowing minimal incomplete functioning. AdoCbl reduces inflamation "radically" more effectively than HyCbl. MeCbl and AdoCbl are 100 ti 10,000 times as effective as HyCbl by my sestimations. That is pretty radical. Also, 400,000,000 years of evolution are on the side of MeCbl and AdoCbl instead of the barely functional salvage HyCbl. HyCbl competes for methyl groups. For HyCbl to be converted to the active forms requires some of the active forms to be present. It rrequires MeCbl, AdoCbl, L-methylfoate and l-carnitine fumarate to produce the ATP and donate the methyl group needed to convert the HyCbl to the same MeCbl that is destroyed by donating it's methyl group. HyCbl is a zero sum game that almost never starts up the methylation needed on the very first level of healing much less the other 5. The whole mercury methylation argument is not valid as stated. 1mg of mecury (takes 30mg of methyl-mercury in serum for symptoms to start appearing) destroys 7mg of MeCbl to be methlated. Since the body contains half that, and since 80% of mecury toxicity symptoms are b12 defciency symptoms, 30 mg of mecury would take all the b12 in your body and all the b12 you could absorb from food or HyCbl for the rest of your life with deficiency symptoms the whole time.
     
    cph13 likes this.
  3. Xara

    Xara Senior Member

    Messages:
    135
    Likes:
    49
    The Netherlands
    I've read an impressive report (Dutch language) of a biochemist who said, if I remember well, that the large part of mercury in the body is kept in the bones. Bones take seven years to be rebuilt completely. So it takes seven years to get rid of all the mercury, the removal and rebuilding process can't be accelerated.
    So I am not worried much about mercury, I'm sure I have mercury but, as far as I understand, it can't be pulled out of the bonecells simply by having lots of chelators available.

    So Freddd, I agree with you. One question though.
    You said
    Am I correct understanding that the body contains only 3.5 mg of mb12?

    Edit: changed word 'recylce' in: 'be rebuilt completely'
     
  4. Sushi

    Sushi Moderator and Senior Member Albuquerque

    Messages:
    7,321
    Likes:
    6,411
    Albuquerque
    Could you please give a reference to a study indicating this?

    Many of the respected ME/CFS doctors prefer to prescribe hydox B12, partly because of its effect on scavenging peroxynitrite. So there are other educated and experienced opinions on the best form of B12 for ME/CFS patients.

    Sushi
     
  5. Lotus97

    Lotus97 Senior Member

    Messages:
    2,015
    Likes:
    423
    United States
    Mercury detoxification is very serious business. The thing I liked about Rich is that he was knowledgeable in many areas besides methylation including Mercury toxicity. I would caution anyone reading this to read Rich's post on the first page about methylcobalamin and mercury. In addition, high doses of methylcobalamin and methylfolate can cause low potassium possibly resulting in death.
     

See more popular forum discussions.

Share This Page