Hopefully this is the correct spot to ask this question. I've searched and not found an answer to this question here already. I've been recommended to take a B Complex supplement but I find that I do not tolerate this well (Thorne B Complex). I'm OK for a day or two but then feel off and don't sleep well. I stop taking it for a few days and improve. I'm working at taking individual B supplements as I believe I need to take them and have a need for B1, B2 and B3. I'm OK with Methylfolate so I don't believe it's this and I also take B12 as Methylcobalamin and Dibencozide Coenzyme. I've read that the reason the B complex doesn't work well for some is due to the body not being able to absorb all of the vitamins at the same time and this has an impact on B2 levels so I want to avoid repeating this taking them separately (thread referencing B2 protocol by dog-person). I've also read that "B1 inhibits B3 absorption. Biotin inhibits B5 absorption" by @Vegas . I've not found any firm guidance anywhere about taking them separately and was wondering what the experiences are and if I'm missing something that has already been posted here. I've taken some Benfotiamine and just started with 9mg of Coenzymated B-2 as a sublingual. I'd like to start adding in some B3 but would like to know at what point I should take this given how it can affect methylation? The B3 capsule is 100mg. Is this a good starting point or should I split the capsule and take a smaller amount?