On Wednesday evening I increased my B1 (Thiamin) dose from 15 mg to 40mg without changing my morning dose. I took 15mg yesterday morning and then 40 yesterday evening. By bedtime last night I had angular cheilitis and edema starting up with paradoxical folate deficiency. It looks like a single dose of 40mg is too much and a daily total of 55mg is to much. I've been taking 8mg daily of Metafolin. I'm going to have to get some 5mg tablets and see where the tipping point is. Such a huge and rapid effect from an additional 25mg of B1 in causing paradoxical folate deficiency is stunning.