Discussion in 'Latest ME/CFS Research' started by *GG*, Apr 20, 2017.
Perhaps a stepping stone to bigger and better studies?
Interesting discussion about the use of Low Dose Naltrexone and at least one of the mechanisms it impacts...Cytokines.
Naltrexone is a medication that has both strong Immune and Neurophysiological effects. "Regular Dose" Naltrexone is used to treat Opiate Dependency and Alcohol Withdrawal. Low Dose Naltrexone is given to provide these effects in smaller measure over a sustained period of time. It has a more systemic impact on improving the immune system, reducing the risk of Immune System Overactivation and in this article reducing the level of Cytokines in the blood stream.
Cytokines are inflamatory agents that scientist think are one of the primary causes of Brain Fog. Also depending on the type can influence pain responses.
"Administration of cytokines to animals can elicit many effects on the brain, particularly neuroendocrine and behavioral effects. Cytokine administration also alters neurotransmission, which may underlie these effects. The most well studied effect is the activation of the hypothalamo–pituitary–adrenocortical (HPA) axis, especially that by interleukin-1 (IL-1). Peripheral and central administration of IL-1 also induces norepinephrine (NE) release in the brain, most markedly in the hypothalamus." Dunn 2006
Could this translate to helping patients with ME? It is a drug with few side effects (first do no harm). Main contraindication is if taking Opiates (most ME patients can't tolerate them). Can be gradually ramped up to therapeutic dose (for those with medication sensitivity/intolerance issues).
So a drug with Neuro/immune effects that could impact the brain fog and autoimmune issues common to ME. Interesting.
They make it clear that it's a small pilot study and they are hoping to do a bigger double blind trial. And to do an ME trial. I guess it all depends on funding.
I'd like to know why it backfires in some people and makes them worse.
I've asked the lab if they had an explanation for it but didn't receive an answer.
From my ME-doctor I learnt that LDN might work, or not, due to my genetics. I was also told to take it in the morning, to avoid insomnia. I started with 0.5 mg´s and increased the dose slowly over some months until 4.5 mg. If it hadn´t worked then, it shouldn´t work for me. There shouldn´t be any reason to increase the dose further according to his experience. FWIW.
Dr. Jeffrey Dach has written some good articles on LDN
At the Open Medicine Institute, I was started at 4.5mg per day and later gradually increased to 9mg. I've been on 9mg for about a year.
So I've never been on a dose of LDN less than 4.5mg.
I find LDN the most beneficial treatment I've found. Stumbling and breathing issues are no longer significantly limiting. Body and joint pain have never been an issue for me (except for a 5 year period ending 20 years ago).
Interesting to hear about quite another dosing and I´m glad to hear that it works so well for you. Your example may inspire to chose other dosages to get a better result.
This 2010 study of MS patients also used 4.5mg.
(note: I had to use the Firefox browser to get this link to display properly).
You can also try a Google Site Search
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