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Reduced pressure pain thresholds in response to exercise in CFS but not back pain

Discussion in 'Latest ME/CFS Research' started by Dolphin, Nov 26, 2011.

  1. Dolphin

    Dolphin Senior Member

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    Full title (I had to shorten)
    Free full text: pdf: http://www.medicaljournals.se/jrm/content/download.php?doi=10.2340/16501977-0595 html: http://www.medicaljournals.se/jrm/content/?doi=10.2340/16501977-0595&html=1

    warriorseekspeace likes this.
  2. Esther12

    Esther12 Senior Member

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    Thanks Dolphin.
  3. Snow Leopard

    Snow Leopard Senior Member

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    NO is supposed to reduce pain sensitivity, which is (in simplistic terms) why it is higher in those with low back pain.
    CFS is associated with a Th2 immune response and one of the consequences of Th2 cytokines is the inhibition of NO synthesis. I know there have been papers hypothesising both high or low NO as part of the pathology of CFS, but I agree with the findings of this paper that absolute expression of NO is not a central factor.

    However there may be downstream factors, eg: http://www.ncbi.nlm.nih.gov/pubmed/9824439 (the NK Cells were not responding to NO activation)
    warriorseekspeace likes this.
  4. WillowJ

    WillowJ Senior Member

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    bookmarking; need to come back later and look at these better; hopefully read the papers. Thanks to both. :Retro smile:

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