A Little Poisoning Along the Road to ME/CFS
Looking at my symptoms, many of which are far less these days and some are gone, it would be easy to figure that I'd just been dealing with some heavy-duty menopausal issues.
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Reduced pressure pain thresholds in response to exercise in CFS but not back pain

Discussion in 'Latest ME/CFS Research' started by Dolphin, Nov 26, 2011.

  1. Dolphin

    Dolphin Senior Member

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    Full title (I had to shorten)
    Free full text: pdf: http://www.medicaljournals.se/jrm/content/download.php?doi=10.2340/16501977-0595 html: http://www.medicaljournals.se/jrm/content/?doi=10.2340/16501977-0595&html=1

     
    warriorseekspeace likes this.
  2. Esther12

    Esther12 Senior Member

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    Thanks Dolphin.
     
  3. Snow Leopard

    Snow Leopard Senior Member

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    NO is supposed to reduce pain sensitivity, which is (in simplistic terms) why it is higher in those with low back pain.
    CFS is associated with a Th2 immune response and one of the consequences of Th2 cytokines is the inhibition of NO synthesis. I know there have been papers hypothesising both high or low NO as part of the pathology of CFS, but I agree with the findings of this paper that absolute expression of NO is not a central factor.

    However there may be downstream factors, eg: http://www.ncbi.nlm.nih.gov/pubmed/9824439 (the NK Cells were not responding to NO activation)
     
    warriorseekspeace likes this.
  4. WillowJ

    WillowJ Senior Member

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    bookmarking; need to come back later and look at these better; hopefully read the papers. Thanks to both. :Retro smile:
     

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