Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Reduced Cardiac Vagal Modulation Impacts on Cognitive Performance in Chronic Fatigue Syndrome

Discussion in 'General Treatment' started by Emootje, Nov 18, 2012.

  1. Emootje

    Emootje Senior Member

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    Background: Cognitive difficulties and autonomic dysfunction have been reported separately in patients with chronic fatigue syndrome (CFS). A role for heart rate variability (HRV) in cognitive flexibility has been demonstrated in healthy individuals, but this relationship has not as yet been examined in CFS. The objective of this study was to examine therelationship between HRV and cognitive performance in patients with CFS.

    Methods: Participants were 30 patients with CFS and 40 healthy controls; the groups were matched for age, sex, education, body mass index, and hours of moderate exercise/week. Questionnaires were used to obtain relevant medical and demographic information, and assess current symptoms and functional impairment. Electrocardiograms, perceived fatigue/effort and performance data were recorded during cognitive tasks. Between–group differences in autonomic reactivity and associations with cognitive performance were analysed.

    Results: Patients with CFS showed no deficits in performance accuracy, but were significantly slower than healthy controls. CFS was further characterized by low and unresponsive HRV; greater heart rate (HR) reactivity and prolonged HR-recovery after cognitive challenge. Fatigue levels, perceived effort and distress did not affect cognitive performance. HRV was consistently associated with performance indices and significantly predicted variance in cognitive outcomes.

    Conclusions: These findings reveal for the first time an association between reduced cardiac vagal tone and cognitive impairment in CFS and confirm previous reports of diminished vagal activity.

    PNS.JPG

    Reduced Cardiac Vagal Modulation Impacts on Cognitive Performance in Chronic Fatigue Syndrome

    Possible treatment options?:

    PNS therapy.JPG
    Parasympathetic nervous system: A new therapeutic target in cardiovascular disease?
     
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  2. nanonug

    nanonug Senior Member

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    There is also an alternative to diminished vagal activity, which is the presence of high levels of vasodilation mediators such as histamine. This is why some people supplement with histidine to effectively lower blood pressure. For example:
    "Oral L-histidine exerts antihypertensive effects via central histamine H3 receptors and decreases nitric oxide content in the rostral ventrolateral medulla in spontaneously hypertensive rats."

    Certain substances are even more potent than histamine, such prostaglandin d2 or bradykinin. All these are released by mast cells.
     
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  3. Emootje

    Emootje Senior Member

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