A Little Poisoning Along the Road to ME/CFS
Looking at my symptoms, many of which are far less these days and some are gone, it would be easy to figure that I'd just been dealing with some heavy-duty menopausal issues.
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Reduce Glutamate synthesis?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by lampkld2, May 4, 2012.

  1. lampkld2

    lampkld2

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    I have a high glutamate/Glutamine ratio on urine AA.

    Anyone know how to shift this more towards the glutamine side?
     
  2. nanonug

    nanonug Senior Member

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    Virginia, USA
    Question: is your glutamine level low, normal or high?
     
  3. richvank

    richvank Senior Member

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    Hi, lampkld.

    You might check your manganese level. The enzyme glutamine sythetase, which converts glutamate to glutamine, requires manganese. It also requires ATP, and increasing that requires getting the mitochondria working better. I think that ultimately this requires raising glutathione, which in turn requires lifting the partial methylation cycle block, but some benefit may be gotten by taking mitochondrial supplements. These include B complex (including biotin), magnesium, lipoic acid, adenosylcobalamin (sublingual), Co Q-10, carnitine fumarate, creatine, and phosphatidylcholine.

    Best regards,

    Rich
     
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  4. adreno

    adreno on the beach

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    NAC will help to clear excessive glutamate from the synapses, and protect against exitotoxicity.
     
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