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Reduce Glutamate synthesis?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by lampkld2, May 4, 2012.

  1. lampkld2

    lampkld2

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    I have a high glutamate/Glutamine ratio on urine AA.

    Anyone know how to shift this more towards the glutamine side?
     
  2. nanonug

    nanonug Senior Member

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    Virginia, USA
    Question: is your glutamine level low, normal or high?
     
  3. richvank

    richvank Senior Member

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    Hi, lampkld.

    You might check your manganese level. The enzyme glutamine sythetase, which converts glutamate to glutamine, requires manganese. It also requires ATP, and increasing that requires getting the mitochondria working better. I think that ultimately this requires raising glutathione, which in turn requires lifting the partial methylation cycle block, but some benefit may be gotten by taking mitochondrial supplements. These include B complex (including biotin), magnesium, lipoic acid, adenosylcobalamin (sublingual), Co Q-10, carnitine fumarate, creatine, and phosphatidylcholine.

    Best regards,

    Rich
     
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  4. adreno

    adreno on the beach

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    NAC will help to clear excessive glutamate from the synapses, and protect against exitotoxicity.
     
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