Phoenix Rising tells QMUL: release the PACE trial data
Mark Berry, Acting CEO of Phoenix Rising, presents the Board of Directors’ open letter to Queen Mary University of London (QMUL) urging them to release the PACE trial data, and hopes that other non-UK organisations will join British charities in the same request...
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Reduce Glutamate synthesis?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by lampkld2, May 4, 2012.

  1. lampkld2

    lampkld2

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    I have a high glutamate/Glutamine ratio on urine AA.

    Anyone know how to shift this more towards the glutamine side?
     
  2. nanonug

    nanonug Senior Member

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    Virginia, USA
    Question: is your glutamine level low, normal or high?
     
  3. richvank

    richvank Senior Member

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    Hi, lampkld.

    You might check your manganese level. The enzyme glutamine sythetase, which converts glutamate to glutamine, requires manganese. It also requires ATP, and increasing that requires getting the mitochondria working better. I think that ultimately this requires raising glutathione, which in turn requires lifting the partial methylation cycle block, but some benefit may be gotten by taking mitochondrial supplements. These include B complex (including biotin), magnesium, lipoic acid, adenosylcobalamin (sublingual), Co Q-10, carnitine fumarate, creatine, and phosphatidylcholine.

    Best regards,

    Rich
     
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  4. adreno

    adreno Learned helplessness

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    NAC will help to clear excessive glutamate from the synapses, and protect against exitotoxicity.
     
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