The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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Red blood cell magnesium and chronic fatigue syndrome

Discussion in 'Latest ME/CFS Research' started by A.B., Jan 7, 2014.

  1. A.B.

    A.B. Senior Member

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    This study is rather old, but still relevant.

    http://www.ncbi.nlm.nih.gov/pubmed/1672392
     
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  2. Valentijn

    Valentijn Senior Member

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    My magnesium tested on the very low end of normal in red blood cells, and high in serum. If I don't take magnesium, I get muscle twitches and loss of gut motility.

    Though once I started Yohimbe, I haven't really needed to supplement magnesium. I used to need magnesium twice per day, and now I just need it once on alternating days, at most. Not sure how Yohmibe is doing that, but I'm not complaining :D
     
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  3. PhoenixDown

    PhoenixDown Senior Member

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    Never got mine in the end, specialist gave me the blood forms but when I got home, local doctors refused arrange to have it done.
     
  4. Lynne B

    Lynne B Senior Member

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    That's really frustrating! Can you return to the specialist's surgery for them to order the tests on your behalf?
     
  5. cigana

    cigana Senior Member

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    Same with me: my red cell magnesium is deficient but blood levels are high.
     
  6. wdb

    wdb Senior Member

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    This paper is on sci-hub is anyone wants to read it. Seems like they did a good job of blinding and controlling for expectation and influence and the results look quite strong. Only weakness I see are that it was quite a small sample (15 in treatment and 17 controls) and only lasted 6 weeks so it's unknown if the effect could be maintained. Also the Nottingham Health Profile looks like a bit of a blunt instrument for example going from borderline yes to borderline no on 'tired all the time' would result in a 39% swing in the score.

    table.png
     
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  7. alicec

    alicec Senior Member

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    I've been supplementing magnesium (both topical and oral) for quite a few years.

    Serum and RBC magnesium are at the top of the range and have been whenever measured over the years.

    I find the supplements very helpful for muscle pain and twitching, sleep and generally feeling calmer, but having high RBC magnesium has done nothing for my ME/CFS. This is gradually getting worse.
     
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  8. bspg

    bspg Plant Queen

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    Hmm, this is interesting. I didn't know one could have good serum magnesium levels but and low RBC levels. I wonder if that's why oral magnesium never seems to do anything for me. I have most of the problems associated with magnesium deficiency but oral magnesium never helps.
     
  9. alicec

    alicec Senior Member

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    Try topical.
     
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  10. bspg

    bspg Plant Queen

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    @alicec does the topical somehow get into the RBC's?
     
  11. alicec

    alicec Senior Member

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    Not particularly but you might get better absorption into the blood using the topical route. This in turn might drive more uptake into cells.
     
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