Received my methylation profile results; requesting interpretations

[mabelark]

Today 23andme presented me with my results. I ran it through the genetic genie. The genie in turn had this to say:

Heterozygous
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MTHFR C677T rs1801133 AG +/-
MTHFR A1298C rs1801131 GT +/-
MTRR H595Y rs10380 CT +/-
MTRR K350A rs162036 AG +/-
MTRR A664A rs1802059 AG +/-
BHMT-02 rs567754 CT +/-
BHMT-04 rs617219 AC +/-
CBS C699T rs234706 AG +/-
CBS A360A rs1801181 AG +/-
SHMT1 C1420T rs1979277 AG +/-

Homozygous
COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
MAO A R297R rs6323 T +/+
BHMT-08 rs651852 TT +/+

I've been experimenting with (amongst many things) methylb12 & metafolin for the last 12 months but my inability to focus, social anxiety and gut issues still remains as my main cause of concern.

I would be most grateful if members from the Phoenix Rising community would offer their help in interpreting my results. Thanks.

 

[taniaaust1]

Genetic genie gave me an analysis which included info on treating the methylation issues which was under the results. Did you scoll down enough to see this? eg part of my genetic genie report (I have many of the same mutations as you do).

"
Nutritional support of MTR/MTRR
According to Dr. Yasko's clinical experience, one should first take into account COMT V158M and VDR Taq status. She finds that those with COMT V158M + and VDR Taq - mutations often don't tolerate methyl donors well. She says that those with these mutations should carefully balance their ratio of Hydroxyl B12 and Methyl B12. She often suggests low dose cyano B12, adenosyl B12, and vitamin E succinate. High dose methylcobalamin (5 mg per day and above) may be implicated and necessary with this mutation - especially if one is homozygous and/or has MTRR + mutations. The level of B12 one needs depends often depends on the number and combination of these mutations. Like everything else, one should slowly build up doses of both methylcobalamin and/or hydroxocobalamin to avoid adverse effects. "

Anyway.. there should analyses of your methylation results under the results (I almost missed seeing that myself).

...................................................................................

"MTHFR C677T rs1801133 AG +/-
MTHFR A1298C rs1801131 GT +/- "

Those two together arent good, having both those together is the same as being homozygous for MTHFR and supplementation is required.

You could also check out the MTHFR website for info on that.
..............

A site Ive been finding great to find out more about my results and what these things do is http://snpedia.com/index.php/SNPedia just do a search there on each of your mutations (Ive been just searching using the rs number for each).

 

[mabelark]

Genetic genie gave me an analysis which included info on treating the methylation issues which was under the results. Did you scoll down enough to see this? eg part of my genetic genie report (I have many of the same mutations as you do).

Hi taniaaust1, thanks for the reply. I did have a look at the analysis offered by the genie - and made a larger than usual order on iherb as a result.

Any recomendations on b12 in particular? Right now I'm on adenosylb12 4,300 mcg, methylb12 1,000 mcg and metafolin 1,600 mcg daily.

"MTHFR C677T rs1801133 AG +/-
MTHFR A1298C rs1801131 GT +/- "

Those two together arent good, having both those together is the same as being homozygous for MTHFR and supplementation is required.

Seems that the gut feeling telling me to try supplementation 12 months ago was on to something. Makes you wonder though what might be implied by supplementation being "required", seeing as I was approaching nearly three decades without ever having any.

A site Ive been finding great to find out more about my results and what these things do is http://snpedia.com/index.php/SNPedia just do a search there on each of your mutations (Ive been just searching using the rs number for each).​

​

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The snpedia software ("Promethease") analysis just finished after taking most of the day. Lots of stuff to go through. Good idea about looking up each individual SNP.​

​

 

[taniaaust1]

Seems that the gut feeling telling me to try supplementation 12 months ago was on to something. Makes you wonder though what might be implied by supplementation being "required", seeing as I was approaching nearly three decades without ever having any

"required" was my word as it helps prevent issues happening sooner or later if one has two copies (something my MTHFR specialist has said). One can get issues and not even realise that it was due to this. In my case my daughter was born disabled due to my MTHFR with an issue similar to spina bifida, my mutation has affected her for life and that could of been avoidable by supplements. Of cause people dont have to supplement but if they dont, they are at risk for all kinds of issues and with this one if left untreated it can increase your risk of heart problems, strokes, miscarriages among other things.

When I went throu my individual problem SNPs and started researching these. . to my shock I found that one of them with just one copy of it, increases my risk of lung cancer even as a non smoker. 26.3% higher risk just with one gene copy. (if I had two copies it would increase my risk up to nearly 40%). Neither 23andME or Geneticgenie had told me about this. My daughter is a smoker so knowing this is important.. she could have two genes so even be at more risk.

My investigation of individual SNPs also is showing me where other issues Im having, my SNPs have played a role. So far Ive only researched half of the mutations which came up on my detox results individually so Im wondering what else Im going to find

[PMID 21674184]
Current evidence on the relationship between CYP1B1 polymorphisms and lung cancer risk: a meta-analysis.
"In this meta analysis, we assessed 10 case-control studies included 7,067 cases and 9,374 controls of the association between CYP1B1 SNPs "
"this meta analysis indicated that individuals with 432GG genotype had a 39.7% higher risk of having lung cancer than those with the 432CC genotype, and individuals with the 432G allele had a 26.3% increased risk as well. "

 

[Critterina]

mabelark,

That's an interesting combo. The BHMT 08 is often helped by TMG, but your other homozygous SNPs could make you sensitive to too many methyl groups. Do you know if you're overly sensitive?

I'm guessing you bought methylfolate, methylB12, possibly Vitamin D and/or TMG. Am I close?

 

[mabelark]

Hi Critterina,

Not sure if I'm sensitive. If I were, would I expect something akin to what is referred to as startup effects? Never had those.

Apart from TMG I'd say you're about right. I tried DMG once and did not feel any difference so I forgot about TMG. I'll make sure to give it a go next. Also got Zinc, Dopa Mucuna, 5P5 and vitamin E.