Professor & patients' paper on the solvable biological challenge of ME/CFS: reader-friendly version
Simon McGrath provides a patient-friendly version of a peer-reviewed paper which highlights some of the most promising biomedical research on ME/CFS ...
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Reading Tea Leaves

Discussion in 'Institute of Medicine (IOM) Government Contract' started by Ember, Mar 24, 2014.

  1. Ember

    Ember Senior Member

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    By Jennie Spotila
    March 24th, 2014
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  2. Ember

    Ember Senior Member

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    According to Jennie, “ME/CFS patients experience more than fatigue after exertion; we suffer from an exacerbation of all symptoms (including immune symptoms), and 'fatigue' is a completely inadequate word to describe the prostration and collapse.” She writes:
    However, the descriptions of post-exertional prostration or collapse vary. The CCC describes the tendency for other associated symptoms within the patient's cluster of symptoms to worsen during Post-Exertional Malaise and/or Fatigue:
    But symptom exacerbation, primarily in the neuroimmune regions, defines Post-Exertional Neuroimmune Exhaustion (PENE) according to the ICC:
    Such differences matter: “If PEM is equated to fatigue lasting more than 24 hours after exertion – which is reported by Gulf War veterans – the argument that post-exertional malaise is unique to ME/CFS falls apart.”
     
  3. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    Actually, the argument might not fall apart even then. What if a large subset of GWI is in fact ME, just ME from particular triggers? If you go back through the epidemics, ME symptoms do seem to vary a bit, cluster by cluster.

    However I do think we need PEM/PENE biomarkers to be sure of anything.
     
  4. Ember

    Ember Senior Member

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    I can't relate to the term "PEM," except as a warning sign.
     

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