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Rare Coenzyme Q10 gene variations in ME patients

Discussion in 'Genetic Testing and SNPs' started by Valentijn, Jul 22, 2014.

  1. Leopardtail

    Leopardtail Senior Member

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    I need to get around to having another crack at LINUX, it may have ironed out the creases by now - medical stuff to do first though.
  2. Valentijn

    Valentijn Activity Level: 3

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    I can only merge about 10,000 SNPs at a time, so it would take forever using Excel :rolleyes: Maybe if I get really really really bored.
  3. SOC

    SOC Moderator and Senior Member

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    Those did nothing for me, even though I took them with fat. I finally ended up with the ubiquinone in the oil-filled gel caps, which do seem to have some effect.

    ETA: Sorry, I didn't look carefully enough. :( The ones linked are oil filled capsules. The Doctor's Best CoQ10 with BioPerine that I took was a dry powder one. I'll have to try this softgel one to see if it works for me since it is cheaper.:)
  4. Mij

    Mij Senior Member

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    @SOC I was under the impression that this brand/form was oil based, it states softgels. In the ingredients list it says oil soft based gel.
    SOC likes this.
  5. Mij

    Mij Senior Member

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    http://lpi.oregonstate.edu/infocenter/othernuts/coq10/#supplement


    Does oral coenzyme Q10 supplementation increase tissue levels?


    Oral supplementation with coenzyme Q10 is known to increase blood and lipoprotein concentrations of coenzyme Q10 in humans (2, 12, 15). However, it is not clear whether oral supplementation increases coenzyme Q10 concentrations in other tissues of individuals with normal endogenous coenzyme Q10 biosynthesis. Oral coenzyme Q10 supplementation of young healthy animals has not generally resulted in increased tissue concentrations, other than in the liver, spleen, and blood vessels (97, 98). Supplementation of healthy men with 120 mg/day for three weeks did not increase skeletal muscle concentrations of coenzyme Q10 (99). However, supplementation may increase coenzyme Q10 levels in tissues that are deficient. For example, oral supplementation of aged rats increased brain coenzyme Q10 concentrations (100), and a study of 24 older adults supplemented with 300 mg/day of coenzyme Q10 or placebo for at least seven days prior to cardiac surgery found that the coenzyme Q10 content of atrial tissue was significantly increased in those taking coenzyme Q10, especially in those over 70 years of age (36). Additionally, in a study of patients with left ventricular dysfunction, supplementation with 150 mg/day of coenzyme Q10 for four weeks before cardiac surgery increased coenzyme Q10 levels in the heart but not in skeletal muscle (101). Clearly, this is an area of research that requires further investigation.
  6. SOC

    SOC Moderator and Senior Member

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    You are right, I goofed. :redface:

    Unfortunately, the only Dr's Best CoQ10 that is oil-based seems to be the low doses. Since I take 600-1200 mg daily, 100mg capsules just won't work for me. :( I took 1200 mg for several months which seemed to noticeably improve my general energy level, but that's expensive. I cut back to 600mg, which is still good, but I notice the difference. I'm considering trying 800 mg to see if that's enough to get the full effect, but the cost is still the problem.

    The CoQ10 I'm taking currently is approximately the same price (11 cents per 100 mg) as the Dr's Best if I buy the 600 mg capsules in the largest packaging (150 per bottle). Needless to say, it's a costly bottle but at least it lasts a while.

    I continue to remind myself that $0.66 -$1.32 per day is not much to pay for noticeably more energy.
    Mij likes this.
  7. Hip

    Hip Senior Member

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    Last edited: Jul 27, 2014
    end and Valentijn like this.
  8. Mij

    Mij Senior Member

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    @SOC I've recently increased my dosage to 200mg/day and for me it seems to be a quicker recovery time. So instead of needing to lie down for 40mins, I feel I can take only a 20min break and move around again. This includes cognitive recovery from reading too much.
    SOC likes this.
  9. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    vitacost brand q10 400mg x 240tabs cost me $45, but it was a buy 1 get 1 free, normally $45 for 120tabs.
    Have to try different brands and find different specials i think because q10 is probably one of the expensive supps.
    merylg likes this.
  10. Hip

    Hip Senior Member

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    That Vitacost Q10 400 mg x 120 for $46 is pretty good value — around $1 per gram.
    merylg and heapsreal like this.
  11. adreno

    adreno 3% neanderthal

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    You have to factor in shipping costs as well, not everyone lives in The States. Iherb has $4 international shipping. How about Vitacost?
  12. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    iherb is $8 for me and vitacost was $14, but vitacost seem to have regular specials on some products like buy 1 get 1 free or the second at half price etc. Nothing beats iherbs shipping cost and speed but when there is a good special it the and not in a rush for your product then shipping isnt as important.

    Its a matter of keeping an eye on the specials but also shipping specials sometimes. I herb recently had a free shipping but it wasnt their usual DHL shipping and orders were taking 4 weeks.

    Some products which are expensive can sometimes be alot cheaper if u cap them yourself and buy bulk powders, this was good for me with phosphatidylserine and OKG but q10 in bulk wasnt any better then the vitacost special.

    Vitacost dont seem to have all their rules sorted out as they wont ship nac to australia for some reason so i mention thied to vitacost and they were going to look into it, so missed out on my buy1 get 1 free.

    got to be a bargin shopper.
    merylg likes this.
  13. Hip

    Hip Senior Member

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    Rather than capping the powder supplement yourself (which is time consuming, even if you use a capping machine), another option is to buy one of those cheap milligram digital wighting scales that you can purchase for as little as $10, and you can weigh out the powder and then swallow it with some water. I do this for several supplements I take daily. Note that some digital scales are only accurate down to 0.01 gram (10 mg), but others are better and have 0.001 gram (1 mg) accuracy.
    Last edited: Jul 28, 2014
    SOC, heapsreal, ukxmrv and 2 others like this.
  14. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Yes it is a pain in the butt even with the capping machine, so i only use it for the powders that work out alot cheaper then pre made capsules etc

    I need to invest in a set of scales u mention, although that would really make me look like a druggy. my teenage daughter said i looked like a druggy when i was capping my supplements the other day, lol. i said to her, hey man this ornithine ketoogluturate is good shit, but dont tell the cops, lol.
    Valentijn likes this.
  15. Hip

    Hip Senior Member

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    Yeah, if the police ever searched my house, I am sure they would think I was selling illicit substances, as I have more than one digital milligram scale here.
    heapsreal likes this.
  16. Valentijn

    Valentijn Activity Level: 3

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    Oddly we can't even seem to buy tiny measuring spoons or empty capsules in the Netherlands, without being part of a registered medical-type company. Other European countries won't deliver them here at all, though we were able to get stuff from China. Not sure if it's official policy or law, or whatever, but it was quite bizarre.
  17. Hip

    Hip Senior Member

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    That seems very strange that they would restrict the import of things like empty gelatin capsules. Though buying from China is often a good option; I bought my digital scales from China at a very good price.
  18. Valentijn

    Valentijn Activity Level: 3

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    We did too, in the same delivery, as an afterthought. But the scale was already unusable, due to the weighing part having been abused at some point. It only cost 10 euros, so we threw it away and gave the shipper a bad review :)
  19. end

    end Senior Member

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    These: http://m.iherb.com/Doctor-s-Best-CoQ10-with-BioPerine-100-mg-120-Softgels/10930 are the most effective softgel CoQ10 I have ever taken and the lowest price I could find - apart from opting to go the "dry powder version" and capping them yourself!

    Have not felt additional improvements on doses above 400mg/day, so I stick to that dose. Good luck
    Valentijn likes this.
  20. end

    end Senior Member

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    True. VitaCost is a rip off for postage, when compaired to iHerbs rates. VitaCost restrict NAC, Metafolin & countless other benign products from being sent to Australia. Why?

    Update: 02/08/14
    VitaCost replied to my email regarding the above mentioned supplements restrictions this morning with a full paragraph of a "non answer"

    "Thank you for contacting Vitacost.comwhere we take the cost out of healthy living. My name is Quaid and I will be happy to assist you.

    Thanks for your inquiry. While Vitacost tries to ensure that products restricted in certain countries are unavailable for purchase by customers residing in those countries, we cannot guarantee our restriction information is always up to date.

    We strongly recommend checking with your local customs authorities to make sure there are no restricted items in violation of your locations import laws."


    I think having to effectively DOUBLE your shipping costs - because VitaCost do not send Metafolin NAC and other benign supplements which has you go else where, also needs to be taken into account...

    @heapsreal

    "iherb is $8 for me and vitacost was $14, but vitacost seem to have regular specials on some products like buy 1 get 1 free or the second at half price etc. Nothing beats iherbs shipping cost and speed but when there is a good special it the and not in a rush for your product then shipping isnt as important."

    - You will find that iHerbs $8 postage is NOT the equivalent of VitaCosts $14.99 postage, as iHerbs postage is superior in multiple aspects

    Vitacosts website via App had multiple deficiencies, it has been recently updated to include website registration after personal correspondence with there "CEO". Overall I think iHerb is a better option, but each to there own! Good luck
    Last edited: Aug 2, 2014

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