Question re brain-fog

[triffid113]

All the hormonal supplements go through the liver. When you have methylation problems, you already have liver problems. Bile salts or choline might help speed up clean up.

Yes, good point. Since DHEA goes through the liver I myself have from time to time worried and thought about changing my delivery method...so I tried sublibgual which does not go through the liver (got no frinkin idea why. anyone?) but it tastes too awful to take it that way. I never got around to investigating a DHEA cream and I know the dose is different (you absorb differently thru the skin) so it's not a simple switch and would involce recalibrating dose. So far I have not hit on a best way. I just take it by pill so far.

 

[stridor]

triffid113
Thank-you for sharing this information.
I was wondering....Do you (or anyone else) know a means by which DHEA &/or pregeneolone would increase energy production? I had a pretty typical ME crash taking these two similar to taking mitochondrial supports like Q10 or carnitine. When I first took them, and unfortunately I took them together and can't identify the main culprit, I had a surge of energy and "wakefulness" and then crashed-out a couple of days later.

I seem to be getting by OK with the testosterone but I am only taking enough to normalize (not augment) levels.
Given my estrogen problems, I think DHEA is a write-off. If I ever try the pregnenolone again (for its purported cognitive enhancement) I will split the capsules. No immediate plans though. Right now it is 'settle on the testosterone' and then revisit ubiquinol.

I read on this site that people low in adb12 will not tolerate Q10. That was one of my first discoveries in 2007. Well, I have adb12 on board now and it is time to revisit this one...in a week or two.

 

[stridor]

triffid113
The reason that sublingual or topical applications are not unduly affected by the liver is because of the portal system. Blood is shunted from the gut to the liver via the portal system for detoxification. Therefore, any meds, supplements we take by mouth can be altered significantly. Some drugs are meant to do this as it is the metabolite that is active and not the drug itself.

Some here will have experienced the "magic" of this when they cooked up their first batch of hash brownies. The metabolite of THC is more potent than THC by itself.

Of course, the things that we take sublingual eventually will be processed by the liver but not before having an opportunity to impact the target organ.

 

[physicsstudent13]

so the zinc can help raise testosterone levels by helping absorption?
I tried a bottle of pregnenelone but I'm not sure what it did if anything. clomid seemed to help energy a bit but it has risk of eye damage/floaters. I tried the Tshots/gels and then I think I had some atrophy with my T levels down to 93. HCG is supposed to be better since it stimulates the testes to produce testosterone instead of replacement which may shutdown and cause atrophy. clomid signals the hypothalamus. I think my low energy is testosterone related and the testosterone also helps fog and brain function.
I'm still terribly exhausted even on the ventilator and have memory damage from low O2 levels. maybe I should try DHEA?

 

[CFS_for_19_years]

DHEA is best taken sublingually so it can bypass the liver. Most doctors and naturopaths recommend having a DHEA-sulfate blood level taken before starting it. Amazon carries several sublingual liquids:

http://www.amazon.com/Davinci-Labs-Liposomal-DHEA-Spray/dp/B0050OBPYQ
(the picture of the product should be a glass bottle, not a plastic vitamin bottle.)

http://www.amazon.com/Apex-Energetics-DHEA-K-18-fl/dp/B007P4T1KE

http://www.amazon.com/Recommended-E...terone-Niacinamide-Pregnenolone/dp/B0093UCHRM

http://www.amazon.com/Natures-Plus-Dhea-Spray-liquid/dp/B0001VUBI4

http://www.amazon.com/sublingual-liquid-supplement-99-9-purity/dp/B006K5K9VO

http://www.amazon.com/Get-Healthy-Again-DHEA-Solution/dp/B001SB5R62

Let us know how it goes.

 

[stridor]

This morning I had the least amount of brain-fog in 2 years 11 months. It was there but only a bit. Had a hard time holding back the tears when I tried to tell people about it. Defintitely related to T that I started 10 days ago. Takes a while to work I guess and when it does it is sudden. Fog increased through the day but that's OK...I think I got a glimpse of my future - clearly