HI everyone, I'm new to this board and am reading through all these threads one after another...I'm actually somewhat researched in methylation issues from some other forums I read. My question is this...is anyone doing remarkably better or "cured" by taking the right methylation supplements? Everything I read on CFS seems to point to methylation blocks and I read people taking large amounts of b12 and methyl donors etc. but I rarely see them report dramatic improvement. It would seem for example, that if the issues were primarily methylation then taking something like SAM-e would result in rapid improvement. My primary symptom outside of terrible fatigue is orthostatic intolerance and pounding heartbeat. I would love to fix this. Is anyone "cured" by fixing these methylation issues or taking things like SAM-e etc.?