My question is: If you saw your CFS symptoms vary with your menstrual cycle (specifically getting worse during the week before your period) before getting any CFS treatment, did this variation improve with: 1. anti-viral treatment 2. antibiotic treatment 3. methylation treatment 4. any other treatment 5. still varies with cycle despite treatment Reason I am asking: I am in quite a mess the last few months. My CFS symptoms had been fairly predictable along with my menstrual cycle since going off long-term continuous birth control in Sept 2012. And then in Aug 2013, I had an ovarian cyst rupture during my period. It was brutally painful, but resolved within several hours. My CFS symptoms became worse throughout the month and I had some ovarian pain. In Sep 2013, during my period, I had another event that felt like an ovarian cyst rupture, though not quite as bad as the month prior. I'm assuming it was the same cyst still resolving though I haven't had it imaged. CFS symptoms were again worse, but no ovarian pain throughout the month. On the 21st day of my cycle (around when progesterone should be peaking), I had an unusual flu-like episode-- I had a day of excruciating bone pain that felt like the marrow was being scraped out of my bones, followed the next day by brutal muscle spasms in my right upper back, followed the next day by more bone pain and a flu-like malaise. During these three days, my usual CFS symptoms were slightly improved, but then came back as soon as the flu episode ended. In Oct 2013, I again had pain during my period, though it was much more widespread throughout my pelvis, and this time resulted in a fever that lasted about 24 hours. My ovaries and pelvis felt very swollen for several days but eventually healed up-- it felt like I had pelvic inflammatory disorder. I am just now at the 21st day of my cycle again, and I am again having a weird flu-like illness, but this time different. This time I am getting these hypoglycemic attacks, along with muscle fasciculations, tachycardia, shaking, and dry mouth, along with a flu-like malaise. They went all night last night and throughout the day today but are now improving. I expect this will go away in the next day or two like last month, but obviously I am carefully watching it. I feel like I have some kind of infection in my ovaries, but I don't have any STDs. And why now am I all the sudden getting these weird flu-like episodes corresponding exactly to when my progesterone should be peaking? We know that progesterone alters the immune system, so it must be somehow related, but it is frustrating. Anyway, I'm about a week away from my next period and scared that I will have another infection flare-up. So for those of you that have had infections dealt with and treated, have you ever seen anything like this? And what the heck is progesterone's problem? And referring back to my question above, I guess I'm looking for clues about whether progesterone affects symptoms of an infection. And to those that are shouting at your screens that I should go get tested for viral titers, lyme disease, cervical culture swab, etc: believe me, I want to!! I am in the process of working on this, but I have been bedbound for a year and my symptoms are so severe that I honestly feel like it would kill me to try and go to a doctor appt, even if there were a doctor near me that would be willing to do these tests. I keep hoping I'll find a supplement that will get me well enough to go to a dr appt, but it is an uphill battle. My pantry overfloweth with supplements.