I was on Folapro only last year and noticed some detox and a lot of improvement in MCS. Maybe a tiny bit of energy improvement for awhile. In February this year I added methyl B12. There was some more detox. In May I added adrenal support. Now it's December and surprise - I no longer need most of my other supplements outside of methylation and adrenal support. I am also tapering off of Zoloft which I've been on for many years due to panic attacks. My energy has been about 5% percent better which is a big gain for me. I've also noticed more improvement in MCS. Also improvement with one or two of my food intolerances. My question is - what do you think is causing the energy increase, no longer needing the Zoloft/supplements, and food intolerance improvement - the adrenal support alone, or the combination of methylation and adrenal support? I took the methylation panel and have a classic CFS profile. I took a 24 hour adrenal test and it showed adrenal fatigue with basically a flat line with a slight rise at night (what my naturopath called one of the worst profiles they've ever seen).