Actually the question is not about transdermal supplements generally as I know you can buy them and I assume that they do something if used correctly. It's a question about one I have made up myself and if it's likely to be doing any good. I discovered some years ago that I was very deficient in Carnitine and according to the blood test I had done via Dr Myhill, I had the lowest score she had ever recorded for this. It has occurred to me recently that I may have a genetic problem with Carnitine but I am pursuing this separately, via my GP. I had it retested 4 years later and my low score previously was still her lowest ever score (and she tests hundreds, probably thousands now). I have been unable to use Carnitine internally as I have an upper gut condition - known as Functional Dyspepsia, but whatever the name, some foods, supplements and drugs especially acidic ones, cause intolerable pain. Luckily my score did increase even without Carnitine, but it was still below the range. This year I had the bright idea of trying out transdermal Carnitine, but I have no idea if it is working - what do people think? I use Acetyl-l-Carnitine powder dissolved in a jar with some transdermal magnesium that has DMSO in it to help carry it through. I apply it liberally to my legs and feet and then put on top my long support socks. I don't really know how much to put in at a time, so it's pot luck there and i have been slowly increasing the amount to dissolve. Would this work do you think?