So after months of dealing with horrible mystery symptoms, I've found a superlative endocrinologist with an 'integrative medicine' flair. The only real marker that has changed over the period in which my symptoms have become debilitating was my TSH migrating from 1.3 to 3.31, and he agrees that the shift might be responsible for my symptoms. He's ordered quite a lot of blood tests -- hormone levels, mineral levels, homocysteine, B12, etc. etc. -- but has also said he's happy to try treatment to see if it ameliorates symptoms, rather than let me suffer endlessly. I'm only seeing him again in 4 weeks and admittedly I am feeling quite antsy and anxious because I really want to get at least partly back on my feet. I'm pretty much flatlined at the moment and totally bedridden (especially after giving up caffeine). What I've been wondering is -- if one's body is in a 'weakened' state where Cortisol is presumably low, can correction of hypothyroidism alone go someway towards ameliorating that, or is it possible that the thyroid treatment might not be tolerated? I've read Cortisol and NE are actually increased in hypothyroidism as a compensatory measure, which is how I felt initially, but after months on end like that I'm presumably burned out now ..