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question about donut hole insufficiency

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Aerose91, Aug 26, 2015.

  1. Aerose91

    Aerose91 Senior Member

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    If one suspects folate insufficiency how are you supposed to jump up to 4-8x the dose of mfolate without throwing yourself right into methyl trapping? Wouldn't you have to largely increase your dose of mb12 along side it? I don't think this is possible for me considering how much mb12 revvs me up.
    I'm currently at 6 mg mfolate and 10 mg mb12 and recently started feeling awful but yet very revv'd uo any any dosage of mb12 over this. If this is potentially donut holing what's the best way to go about it?
     
  2. minkeygirl

    minkeygirl But I Look So Good.

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    I think the ratio if mb12 to methylfolate is 2:1.
    Beyond that I'm clueless.

    Maybe @PeterPositive can help.
     
  3. Aerose91

    Aerose91 Senior Member

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    Thanks, minkey. Freddds protocol is so all over the map I don't ever feel comfortable trying to progress it
     
  4. ahmo

    ahmo Senior Member

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    You won't necessarily need to increase the B12. What are your low folate symptoms?

    Here are some comments from Fred, from page11-13 A Guide to Freddd's Protocol
    http://forums.phoenixrising.me/index.php?threads/should-i-reduce-my-b12.29096/

    Question: methyl folate can range from 400, to roughly 1600mg a day.. Do you think that low dose of folate would even trigger paradox deficiency? It seems most people that had that were using much higher doses...

    Simplified Understanding of Folate

    http://forums.phoenixrising.me/index.php?threads/problems-beginning-methylation- needing-some-direction.28302/#post-432943
    http://forums.phoenixrising.me/index.php?threads/need-large-amounts-of-mfolate- throughout-day-and-potassium-but-potassium-opposes-mf-help.25857/
     
  5. Aerose91

    Aerose91 Senior Member

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    Thanks for sending these, @ahmo and thanks for the continued help. One thing I question though, it says on the last paragraph there that only 100 mcg of mb12 absorbed may cause a need for up to 30 mg mfolate. Pretty much every source I've ever heard says that mb12 should outweigh mfolate at least 1.2:1, otherwise you are risking methyl blocking. Unfortunately methyl blocking has almost the same symptoms of donut hole insufficiency (if I remember correctly) so how can you tell if you have solved one and not moved on to the other?

    My symptoms as of late are emotions all over the place (depression to solemness to anger etc..), i have more "nothingness" in my brain, confusion sometimes to the level of psychosis, auditory halleucinations, muscle achiness and pain, acne.

    Important to mention that this whole disease is in my brain anyway so none of these symptoms are atypical, i have many more psychological symptoms just that these have become worse as of late.
     
  6. ahmo

    ahmo Senior Member

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    Have you tried lithium? It apparently helps B12 transport, also corrects mood imbalances. I felt the difference within hours of my first dose, my emotional lability disappeared. Your symptoms sound very like mine have been. Each step I've taken has relieved my brain and nervous system, until they're more or less *fixed*.

    Have you looked into pyroluria? I'm linking a questionnaire. Just adding the correct supplements made a big difference for me. And coffee enemas to clear liver and adrenals. After detoxxing for a year, I had a major clearing of my adrenals, which seemed to bring with it almost a reset to my temperament: irritability, agitation, low tolerance of frustration...things which had plagued me for decades, now only appear under extreme stress or need for detox.

    I'm afraid I can't answer this. Maybe @whodathunkit can. Here's another thread, maybe your symptoms overlap.

    http://www.hputest.nl/evraag.htm Online questionnaire to suspect pyroluria
    Pyroluria/Lyme protocol.
    http://www.lymeinducedautism.com/images/1_KlinghardtKPU_09_PX.pdf

    Here are some notes from Fred. The first one is from whodathunkit.



     
    Last edited: Aug 27, 2015
    whodathunkit likes this.

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