GP has tested for some vitamins, B6, B11 and B1 were waay too high. as I have had tingling handpalms for many years, GP thinks that is caused by intake of B6 and told me to stop the supplement. I did. I've been searching for info. I took a Bcomplex with 10 mg of B 6, that's not very high. And its P5P (pyridoxical5phosphate). even though it is sometimes thought that B6 as P5P will not cause tingling/neuropathy, there's not proof for that. So the assumption that the tingling is indeed caused by too high bloodlevels is probably valid. several things pop up with me. but the question is, why does my body not use the stuff... 1) the body misses some key-ingredient to use it ( my intuition says zinc, yay, but that's just intuition...). when googling I find things like: Vitamin B2, B3 and zinc are needed to convert pyridoxin into P5P. But as I take it as P5P that doesn't help me. 2) the stuff is in my blood but does not go into the cells. ( why?) 3) I've started taking B12, shortage of methylcobalamine does explain the high folatelevel I think. (very new to the methylation-knowledge, reading diligently, but my what an amount of complex info) But is the same connection to be found with B6?? seeing that Myhill ( who follows the protocol of Richvan) prescribes 2 x 50 mg P5P, i think it is) I suppose it is a combination of these, plus who knows what, any information on this topic would be very welcome. ( oh, and since I take metcob, the soles of my feet started to tingle too. Might be coincidence, might be that I'm more aware of what goes on in my body, might be...what ???