1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
A Little Poisoning Along the Road to ME/CFS
Looking at my symptoms, many of which are far less these days and some are gone, it would be easy to figure that I'd just been dealing with some heavy-duty menopausal issues.
Discuss the article on the Forums.

quercetin, yes -- but adding bromelain?? probably no

Discussion in 'General Treatment' started by Sherlock, Sep 4, 2012.

  1. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

    Messages:
    807
    Likes:
    295
    Czechosherlockia, USA
    Quercetin is said to have problems with absorption. As a result, it is sometimes sold combined with bromelain, which comes from pineapple, to increase absorption. Quercetin is also said to increase absorption of drugs like penicillin.

    However, the MOA is that (as being composed of one or more proteases), bromelain likely increases gut permeability, which seems like a bad idea for people here.

    Also, here's a study with heparin:
    "Improvement of the intestinal membrane permeability of low molecular weight heparin by complexation with stem bromelain."
    2006 http://www.ncbi.nlm.nih.gov/pubmed/16950580

    which gets more complicated because intestinal mast cells do contain heparin

    - and btw medical heparin is derived from animal intestines (and lungs).
     
    SickOfSickness likes this.
  2. Dreambirdie

    Dreambirdie work in progress

    Messages:
    5,128
    Likes:
    3,398
    N. California
    interesting. Thanks.

    I take a high potency quercitin called ISOQUERCITIN, that I get from my naturopath's office. It has no bromelain like the commercial brands I have taken. It's made by Integrative Therapeutics Inc.
     
  3. Little Bluestem

    Little Bluestem Senescent on the Illinois prairie, USA

    Messages:
    2,684
    Likes:
    2,016
    Midwest, USA
    I used to take quercitin and bromelain for allergies. When I read that quercitin can interfere with liver function, I switched to bromelain and tumeric. I guess I will have to find something else.
     
  4. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

    Messages:
    807
    Likes:
    295
    Czechosherlockia, USA
    Hi, Bluestem. Are you referring to how quercetin interferes with breaking down pharmaceuticals? I put a list just today here: http://forums.phoenixrising.me/index.php?threads/quercetin-is-a-bioenhancer.19221/

    Here's a much longer list from webmd:
    http://www.webmd.com/vitamins-suppl...gredientId=294&activeIngredientName=QUERCETIN

    Elsewhere, I'd seen that an FDA approved formulation of some drug with quercetin resulted in using only 60% of the amount of drug that had been previously alone - so it's not necessarily a bad thing as long as it's properly accounted for.


    But aside from that, I see that quercetin can be very helpful to the liver in conditions like cirrhosis or fatty liver disease. Ah well, so many supplements claim to be great for so many things - but at least claiming a benefit is better than having to point out a known danger :)
     
  5. Little Bluestem

    Little Bluestem Senescent on the Illinois prairie, USA

    Messages:
    2,684
    Likes:
    2,016
    Midwest, USA
    I read that quercetin might slow down phase I detox. I think I also read that some PWME have phase I running faster than phase II, so that might not be a bad thing in some instances.
     
  6. carolwxyz99

    carolwxyz99 Senior Member

    Messages:
    114
    Likes:
    10
    I take quercetin as I was advised to take it for breast cancer prevention, as it came up positive in a research in-vitro test against my cancer cells. Do you happen to have a link to where you read that quercetin may slow down phase I detox? Thanks.
     
  7. adreno

    adreno 3% neanderthal

    Messages:
    2,586
    Likes:
    1,944
    Tundras of Europa
    Quercetin is also a phytoestrogen, which might not be so good for males.
     
  8. Little Bluestem

    Little Bluestem Senescent on the Illinois prairie, USA

    Messages:
    2,684
    Likes:
    2,016
    Midwest, USA
  9. Rolo

    Rolo Too ill to twist

    Messages:
    29
    Likes:
    11
    Antwerp, Belgium
    Hi Sherlock,

    Your conclusion confuses me. I thought bromelain was just healing the gut lining. I'm far from a medical specialist but I would think that they mean something else with "Improvement of the intestinal membrane permeability" . Namely an improvement of the normal uptake through the membrane the epithelial cells and NOT between the cells.

    Especially the conclusion ath the end "This study provides evidence that heparin and bromelain form stable complexes leading to a significantly improved uptake of heparin" let me think that this has nothing to do with "leaky gut"

    Could somebody confirm or deny my assumption.

    Thanks, Rolo
     
  10. Lotus97

    Lotus97 Senior Member

    Messages:
    2,015
    Likes:
    423
    United States
    Quercetin also increases nitric oxide and glutathione.
     
    Sherlock likes this.
  11. Lotus97

    Lotus97 Senior Member

    Messages:
    2,015
    Likes:
    423
    United States
    What about taking bromelain with food as a digestive enzyme? Would that be as damaging as taking bromelain on an empty stomach like many people do (either with or without quercetin)? I decided I'm going to stop bioperine due to its affect on gut permeability. I might stop bromelain too. I hate to waste supplements though...

    Also, why is recommended to take vitamin C with quercetin?

    And someone started a thread on quercetin's effect on mitochondria and fatigue
    http://forums.phoenixrising.me/inde...ect-on-mitochondial-production-fatigue.22356/
     
  12. SickOfSickness

    SickOfSickness Senior Member

    Messages:
    1,881
    Likes:
    962
    US
    I was taking Q and B together, but they give me a fever. I suspect that Q alone would too.

    I also read you should take breaks from them. Taking them continously is bad for some reason.
     

See more popular forum discussions.

Share This Page