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quercetin, kidney damage

Discussion in 'Mast Cell Disorders/Mastocytosis' started by Sherlock, Dec 9, 2012.

  1. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    Czechosherlockia, USA
  2. camas

    camas Senior Member

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    Thanks for the warning, Sherlock.
     
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  3. alex3619

    alex3619 Senior Member

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    This is not a surprise. Quercetin has been suspected of altering eicosanoid production. A number of eicosanoids regulate proper blood flow in the kidneys. So long term use may alter blood flow and even tissue repair.

    I suspect that other substances including resveratrol, which I am taking, may have the same effect if misused.
     
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  4. Changexpert

    Changexpert Senior Member

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    Darn it, I took quercetin for about a month in the past. No wonder my symptoms got worse during that period.
     
  5. Sushi

    Sushi Moderator and Senior Member Albuquerque

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  6. Gondwanaland

    Gondwanaland Senior Member

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    In addition, flavonoids antagonize B1
     
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  7. GracieJ

    GracieJ Senior Member

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    What is a safe dose to be on and for how long? I started quercetin a week ago with great results, and had been planning to bump my daily dose up to the 1500mg recommended on several sites. As it is, right now I am at 1gm per day, which is considered a high dose.

    What do I need to look for to do this safely? The results so far are phenomenal. Breathing, swallowing, digestion, arthritis, and skin issues have all settled down, giving me relief.

    However, at the same time, I started getting headaches as of yesterday, and have had kidney pain for two days with no explanation. Is this something to use for a few days at a time, then stop?

    I think I will back this off to one 500mg capsule daily until I know more.
     
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  8. GracieJ

    GracieJ Senior Member

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    Would you mind explaining that, or giving me some links to understand it?

    Thanks.
     
  9. CantThink

    CantThink Senior Member

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    Source: Quercetin | University of Maryland Medical Center

    The other source quoted by Sherlock said:

     
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  10. Changexpert

    Changexpert Senior Member

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    FWIW, I took 800 mg along with 185 mg of Bromelain. Quercetin must be combined with Bromelain for best absorption. Most people use somewhere around 500 mg and 1000 mg. There was a rat study suggesting that consumption of Quercetin at 50 mg/kg body weight would lead to brain tumors. This means for average females around 2.5g/day and average males around 4g/day, assuming 50 kg and 80 kg respectively.

    Source: http://www.sciencedirect.com/science/article/pii/S0278691513007473
     
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  11. Gondwanaland

    Gondwanaland Senior Member

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    Flavonoids contain an enzime called thiaminase that binds to thiamine and inactivates it.
    The Vitamins
     
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  12. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    From the webmd page:
     
  13. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    When we hear of how grapefruit interacts with medications (making them in effect stronger by inhibiting breakdown in the liver via CYP3A4 and CYP2C9 enzymes), it seems that quercetin is the component in grapefruit that does so. This relates to @Sushi's comment above.

    Also, with kidney pain I'd wonder if there is some pre-existing kidney problem.
     
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  14. GracieJ

    GracieJ Senior Member

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    Thanks, everybody, I did read both links.

    Just sorting out all the pieces, very much appreciate hearing from others about their experiences.
     

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