so... I recall Ron Davis saying that the conversion of pyruvate into acetylCoA was somehow blocked in CFS patients. then there's the fluge/mella study showing lower levels of pyruvate dehydrogenase, the enzyme that catalyzes that reaction. So then I looked at what is a treatment for pyruvate dehydrogenase complex deficiency, and also symptoms of that disease. That disease seems more severe in some ways than CFS, but I wonder if that is simply because it comes on earlier... or is a more complete deficiency in pyruvate dehydrogenase than CFS is. One of the main problems seems to be the buildup of lactic acid, which people with CFS also have. One of the treatments is a ketogenic diet. One of the other treatments being investigated is phenylbutyrate therapy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102924/ Has anyone here tried keto or phenylbutyrate therapy with any success?