I am self-navigating out of CFS and I seem to have approximately 70% of the symptoms on pyroluria checklists. I have no dream recall, pale skin, premature gray hair (starting at age 13), severe inner tension, anxious / fearful, had fingernail spots, light & sound sensitivity, love spicy food, dislike changes in routine, etc, etc, etc. When under stress I developed mild vocal repetitions (tics). My immediate family members have most of these symptoms too... and my mom and brother have little or no sense of smell or taste (zinc deficiency?). I sent away for a urine pyrrole lab test and a bottle of B6 (P5P) Sublingual 25mg. The B6 arrived first and I tried some. I got an powerful, immediate unmistakable healing reaction from just 1 tablet. I felt a huge shift in less than 10 minutes that I interpret as a vitamin B6 deficiency. 50mg p5p per day: cured chronic "wired at night" insomnia problem cured with 1 bedtime tablet improved mood eliminated vocal tics Fearfulness / OCD greatly reduced - replaced with feeling that "everything is OK in the world" The pyrrole test instructions said I had not take any B vitamins and mineral supplements for 48 hours and it was extremely difficult to do this, seeing how much better I felt on the B6. But I took no supplements or drugs for a weekend and sent in the test according to exact instructions. My pyrrole test results were INCONCLUSIVE- "Not able to preform test due to unknown interfering substance in urine. Extremely rare." The test solution turned yellow instead of the expected mauve. A couple weeks ago I started to take Tanalbit (zinc tannins) for candida - and my dose has over 80mg of elemental zinc per day. I noticed that my vocal repetitions (tics) returned out of nowhere. I thought this might be related to ZINC-B6 imbalance so I increased the dose of P5P to 100mg per day. I felt a little bit of twitching,... some neuro periphery (tingling) type weirdness... while I adjusted but then overall excellent. I feel this strong feeling of "everything is gonna be OK, I'm safe, I can handle it, I feel good" On the 80mg elemental Zinc / 100mg P5P sublingual (for the past 4 days) I feel remarkably good much of the time... with occasional, transient moments bits of lower energy or weirdness. Questions: 1. Is is very important to shell out more $$$ for another pyrrole test or can I just diagnose by these symptoms and my responses? 2. How important to be under a $doctor'$ care? Is this dangerous to just experiment with some Zinc & B6 (I am considering 30 - 40mg of elemental zinc and 75 - 100mg of B6s for long term) (Some users (like @Martial ) say it's important to be under a doctor's care. This Kilnghardt powerpoint on KPU talks about metal detoxing issues. Others like @ahmo did not do testing and had success, I believe.) 3. Anyone have a personal pyroluria treatment plan, supplement ratios or protocol to share?