I am new enough here to realise you may have dealt with this enough - I did find a relevant thread but I've lost it again. I had a real breakthrough with my (young) GP yesterday, armed with the latest IiME newsletter and the NS piece on Rituximab. I could almost see the possibility of a paradigm shifting in his eyes. He said that no one in the NHS would prescribe it - that it's a small study etc which is true of course, but he would write supporting letters if I found anyone willing to run a pilot. I am seeing Dr Weir in a few weeks and will talk about it to him. I feel that even a successful pilot in this country could have enormous potential for change. I would be really interested to understand the nuts and bolts of what it would take. On one level it just takes two infusions of an £800 drug. On another level it takes a Dr to stick their head over the parapet and question a powerful consensus.