Awhile ago there was mention of people using very low doses of valcyte like 1/2 pill a day, it was also mentioned that they arent meant to be cut either. Another thing mentioned was using it in an intermittent fashion and i think someone was using it twice a week as they were having bad die off reactions. I also understand that there maybe a possible resistance but think this is alot more common in antibiotics. SO anyone who has used this method can u teel me if this has helped?? Now i have been on valcyte for a few weeks at 1 tab in the morning and famvir at night. Its now long enough to realise im having some type of reaction or die off etc as i feel like crap, worse then my recent cfs symptoms and feeling depressed which isnt normally a problem for me, everything seems so much harder. So to test this theory out, today i missed my valcyte dose and took famvir instead and i had a much better day with all my symptoms improved. Tomorrow i will take valcyte again and see what happens. Im not sure if these increases in symptoms/die off are helping me in the long run or not or that valcyte just doesnt agree with me?? just dont know. So depending what i find in the next few experiment i may alternatevalcyte dosages and continue famvir daily. Would like to know others experiences and opinions. cheers!!!