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Pseudo-jaundice (Pseudo-icterus) and vitamine A metabolism

Discussion in 'Skeleton, Skin, Muscles, Hair, Teeth, and Nails' started by pattismith, Aug 29, 2017.

  1. pattismith

    pattismith Senior Member

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    I don't know if some other are concerned by this condition but I am and I only got the key of it today!

    You may be carriers for polymorphism at "rs12934922 and rs7501331 , two snp that control a person’s conversion rate of beta carotene into retinol. People who have the T allele on both rs12934922 and rs7501331 convert beta-carotene to retinol 69% less efficiently than those without the T allele. For people with only a single T in the rs7501331 SNP, the conversion is decreased by 32%." (this is my case)

    The more you eat carots and tomatoes, the more carotene will increase in your blood, dying it and your skin with a nice yellow color (xanthoderma)!
    I like very much both of them, so you figure my good looking for so long (although my bilirubins levels were always low).
    Hopefully caroten is not toxic, but the lack of conversion from carotene to retinol may be associated with retinol deficiency in some cases (especially vegan people)

    apart from genetic polymorphism, some conditions may increase hypercarotenemia:

    hyperlipidemia, diabetes mellitus, hypothyroidism, porphyria, hepatic disorders, anorexia nervosa, and renal disease

    And vitamine A is important for so many things, steroid hormons metabolism and so on!

    https://www.geneticlifehacks.com/beta-carotene-conversion-to-vitamin-a/
    http://www.healthfrom.com/Symptoms/view-4849.html
    http://emedicine.medscape.com/article/1104368-overview
    http://www.nejm.org/doi/full/10.1056/NEJMicm950425#t=article
    https://selfhacked.com/blog/importance-real-vitamin-retinol/
    https://www.ncbi.nlm.nih.gov/pubmed/19103647?dopt=Abstract
     
    MeSci and pamojja like this.

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