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Provigil/Modafinil

Discussion in 'General Treatment' started by SallyG, Oct 20, 2015.

  1. SallyG

    SallyG

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    Hello everyone,

    I'm hoping someone might be able to help me. I commenced Provigil 200mg OD in the morning around 8 weeks ago. It completely changed my life around. My insomnia disappeared. I felt amazing! However, around ten days ago I took a turn for some unknown reason. I'm now absolutely exhausted, my pain is now horrific and I now pretty much bed bound again. I'm just wondering if anyone has experienced this before? Perhaps I have quickly become tolerant to the dose and need to increase it. I'm just really struggling to cope mentally and physically after getting a taste of "semi-normal" life again and now it has all slipped away.

    I would be so appreciative if you could offer me some advice. Thank you
     
  2. paolo

    paolo Senior Member

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    Italy
    Sadly provigil is not a cure for a condition like CFS. It may give you some short term relief, though. I also use it, but only for short periods of time. Taking provigil, for a CFS patient, is somehow the same as taking it for a person who has a flu.
     
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  3. minkeygirl

    minkeygirl But I Look So Good.

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    @SallyG When you use a stimulant and go past what you normally could do, it's not natural for you and inevitably you will crash.

    That is most likely what happened to you. As @paolo said, it's not a cure or even a treatment. It's a bandaid to get you through a tough day.

    Look around here. There are threads where people talk about this. One is @heapsreal. but there are more.
     
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  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    My advice would be to stop modafinil for a few weeks atleast. Then try lower eg 50mg but have a lower expectation of what 200mg was like. Try to use it intermittently . Than try slightly high doses on an intermittent schedule if u think u need more.

    Also , every so often try to take a week or longer break from it has this helps reduce tolerance .

    I think 200mg may have masked your fatigue too much and or used it too long in a row and cause a crash??

    Time to rest aggressively , maybe some b12 shots may help your nervous system to recover some??
     
  5. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    Just thought I would post this anecdote from the BBC about someone's experience with modafinil, in case it is useful.
     
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  6. Chriswolf

    Chriswolf Senior Member

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    So to clarify, does this medication basically tap you of your catecholamine reserves and then leave you with an empty gas tank as it were? Or does it simply affect the receptors in a way so that they shut down?

    I was thinking myself about approaching the subject of a medication like this with my doctor, although I suspect he won't be so receptive. I am still however interested in what everyone knows about this medication via personal experience, or otherwise.
     
  7. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I only use a low dose, 50mg, normal is 200mg. I feel like it just turns my brain on and concentrate better. I guess it can mask fatigue and u could push beyond your limits and crash. If u dont push way beyond your limits and dont use it all the time, i dont feel like its emptying the tank.

    Just like many antidepressants , it makes the neurotransmitters last longer than they would normally , not stimulating the adrenals to pump out more adrenaline etc

    Its trial and error as everyone is different . I know non cfsers who have used 50mg dose of modafinil and felt nothing. They needed to use 200mg, but maybe they are after more stimulation , not just cognition being turned on.
     
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