I know this has been discussed before, however, I have some different questions. First, a quick snapshot of me(y)/ME 18 Months of fatigue, sleepiness, leg pain,weakness, diagnosed Hypothyroid Oct 12 plus Hashimotos antibodies. Thyroxine fixed thyroid blood levels but not fatigue. Had months of gut problems and headaches have been helped by diet change. Diagnosis 1 GP This GP has known me for 15 years and knows the "whole" body/mind story. And is a fantastic caring GP. She referred me to the two specialists (CFS Physician and Endocrinologist) because I was sick for so long and we had tried every other test, gastroscopy, scans, all bloods, stool, urine tests and brain scans. Her recommendation, -Dont buy into the CFS, she has had other patients who have had viruses for 2 years or more that have gradually gotten better. (?) She is also concerned re: the use of stimulants. Diagnosis 2 CFS Specialist Melbourne (Aus) CFS specialist has given me a diagnosis of CFS in June 13 and has recommended PACE and GET. Has also said that he believes CFS comes from suppressed unresolved anger, grief and fear. And that psycotherapy/counselling can help. Well have had loads of that all my life. Ive had more psychologists/counsellors/psycotherapists than I've had boyfriends. Also to try Modafinil, recommended dose 100mg for wakefulness and B12 injections. But basically said very few adults with this disease ever get back to full time work functioning. That really depressed me because work was very if not "the" most important purpose in my life before getting ill. Diagnosis 3 Endocrinologist . None yet. However had Cortisol tested and its in the low range. So am going for a Syncathen test this week. Potential for Addisons disease or other Pituatary problems eg: tumour. Modafinil Questions (NB: I've had 2 days of 50mg - as recommended by specialist progressing to 100 mg. I did have 1 day off in between to ensure I wasnt going downhill.) 1. Besides fatigue and sleepiness (usually sleep between 2-3 hours from 11am-2 pm plus 9-10 hours per night) I have an overwhelming feeling of "I have to put my feet up". Can Modafinil help with this? If not, is it harmful to my health/the illness to be awake when my body/mind wants to rest/sleep? 2. From your experience with Modafinil can pushing through a previous rest/sleep cycle help you? 3. For people with depression or whom are taking anti-depressants can Modafinil affect your mood? 4. Has anyone with CFS used this long-term successfully? Has your work capacity improved and your health? 5. I found an author who had MS, said it gave her her life back (her mind, concentration and ability to write) and she noted that it had no physically ill effects on her. Has anyone had this experience? 6. Whilst this drug affects people differently, has this significantly affected your health negatively in the medium term? My Experience Inconclusive as yet. The first day, after 50mg I stayed awake the whole day and did yoga and rode to the market (30 mins there and back). I usually ride there once per week but not with the yoga. Found It hard to wind down, felt a bit hyper. Day 2 nothing as I wanted to be sure I didnt go into a crash. I slept as usual for 2 hours and felt more tired than normal. Day 3- 50 mg 8 am. Still felt like lying down at 11, needed legs up. And have been on the couch most of the day. Still not sure if not letting myself sleep and lie down 2 days ago has caused more fatigue than normal. Your thoughts?