The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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ProHealth Survey RESULTS: Antidepressants for ME/CFS and Fibromyalgia

Discussion in 'General Treatment' started by Firestormm, Nov 18, 2013.

  1. Firestormm

    Firestormm

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    I found the results from this survey rather interesting. Looks to have been a well conducted survey - though I can never find the time to properly read these things:

     
    peggy-sue, Helen, beaker and 3 others like this.
  2. barbc56

    barbc56 Senior Member

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    What some people don't realize, myself included when first diagnosed, is that antidepressants help with pain. Long story short, when I moved and told my doctor what dose I was taking of Zoloft, I told him half of what I had been taking and three months of increased pain levels my doctor said we need to increase the Zoloft and it was then I realized what had happened. When looking over my previous records I discovered that there was indeed a discrepancy! The pain did decrease, but it's all relative. Darn fog!!

    I don't remember why Tramadol is not considered an antidepressant and will have to look up this information.
     
  3. justy

    justy Donate Advocate Demonstrate

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    Two doses of an SSRI left me with severe Akathisia, anxiety, agoraphobia and suicidal ideation that lasted nearly two years - I was not depressed when given the anti d nor was I in pain.

    I can say that it was the most horrifying and tortous experience of my life and its amazing that I survived it as nothing gave any relief and Doctors did not belive two doses of an ssri could cause that.
     
    peggy-sue likes this.
  4. Helen

    Helen Senior Member

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    I think all gene tests for SNP´s in the methylation cycle, that have been posted here have showed mutations that might affect both vitamin B12 and methylfolate metabolism. My guess is that most of them have B12 and/or folate deficiencies . Each of these deficiences has been proved to be able to cause depressions.

    So my second guess is that B12-and/or folate deficiencys have caused symptoms of depression, and as doctors in common are ignorant about signs and symptoms of either deficiency they try to treat the symptoms with antidepressants.

    @justy, what a sad story about your antidepressant experience.
     
    justy, Crux and peggy-sue like this.
  5. barbc56

    barbc56 Senior Member

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    How awful.

    It's so important to get a psychiatrist who is up on the different medications. I actually became hypomanic on Wellbutrin. SNRI's make my BP spike as well as tachycardia and they are the ADs that are better for pain.

    In my case, antidepressants literally saved my life. I started taking Zoloft decades before I got sick. If you need them, it can be trial and error finding not only the type of AD but also the dosage and this whole process can be very frustrating.

    Any psychiatrist worth their salt should make sure you have had a recent physical. I was in a bad slump and when my psychiatrist ordered blood tests, it turned out I was hypothyroid and needed synthroid and not an increase in the dosage of Zoloft.

    Years ago, I was deficient in B12 but didn't notice that much of a difference. However it is reassuring that my levels are normal.

    We all react differently, don't we?
     
    justy likes this.

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