I have mentioned this in a few related topics related to this, but thought a topic on its own might get me more answers/experiences. Progesterone therapy isnt just for women but also for men, for sleep it has the ability to improve gaba recptor senstivity which is our main sedating hormone require for sleep. Studies have shown increase in deep stage 4 sleep, growth hormone and general improvemnent in sleep. It also has the ability to help with anxiety. progesterone also has an effect on adrenal fatigue and helping with increaseing cortisol levels and can also help with estrogen dominance my helping lower estrogen, this can the help increase insulin sensitivity and helping weightloss, cholesterol. It seems to be a hormone that balances and tops up other hormones. Now what Im are after is personal experience with transdermal pregnenolone cream and what doses used. Common male doses are 5-10mg, females 20mg. cheers!!!