Hi, So I just got back a few test results from my doc and was wondering if you could help me? I feel it is necessary to fill in some back story in places, some of that info I feel will also be helpful to some people too. Firstly the Complete Male Hormones Profile from Genova Diagnostics shows I am low in pregnenolone and DHEA (borderline low). i have read that mercury can cause a reduction in pregnenolone in Andy Cutler’s book “Amalgam illness” so I have ordered some from iherb and will give it a try. Methylation is also poor due to low levels of the methylated estrogens (good estrogens). Estrogens are generally low across the board (except 2-Hydroxyestrone (2-OHE1), this is probably because I was taking DIM at the time which is an aromatase inhibitor. It also encourages conversion of the bad estrogens to good estrogens hence the good 2-OHE1 result. I think estrogens are generally low also because pregnenolone is low causing less testosterone to be aromatised to estrogens. Any thoughts on this? I also got my red cell magnesium back which was slightly low. I am now currently injecting 0.5ml of magnesium every other day. This helps with my energy quite a lot, I understand mag has a part to play in methylation too? I had a urine DMSA provocation test done also. I have had this once before approx a year and a half ago which showed very high levels of aluminum, mercury, lead, arsenic, barium, copper and nickel! Basically I was a walking toxic dump! The most recent test that came back showed aluminum still quite elevated mercury reduced by more than half, lead is lowered by more than half, arsenic practically gone, barium not detected, copper still high and nickel within limits but still quite high. I took DMSA for 6 months to clear my body burden, I was taking 125mg a day 6 days a week (sundays are lazy!) with breaks. My severe acne disappeared soon after this as did some other annoying problems too. I then added in ALA with the DMSA at a dosage of 100mg a day, same schedule. Things started looking up but chelation is tough sometimes! I am currently only using DMSA as according to Andy Cutler (Amalgam Illness specialist) ALA increases copper retention and could explain why I am still struggling with copper (the white lines/spots on the nails can indicate a zinc deficiency due to copper). To lower copper I am taking 100mg zinc and 2,000mcg of molybdenum daily. I have noticed I felt a little more ‘normal’ since doing this. The white lines on my fingernails are fading and growing out too. Strange! Copper also blocks zinc, folate and B1 so I want less of it! I understand people will tell me that this schedule goes against Andy Cutlers idea of perfect chelation however as I far as I am concerned I wanted to get this stuff out of me as fast as I could without causing too many side effects. It seems to be working for me. I am now currently taking TMG 1,000mg which has improved my allergies (wheat, dairy, yeast) and energy. I experienced diarrhea for a week or so after introducing TMG and then noticed after this that I could tolerate starchy foods again i.e. potatoes, parsnips and cooked carrots. These would normally give me bad diarrhea. I have only started taking TMG recently so the test was performed before I started taking it. However before the test was done I was taking methyl B-12 and folinic acid (5-Formyl Tetrahydrofolate) so clearly methylation was still poor despite this. I have tried methyl folate in the past but simply cannot tolerate it, it makes me feel extremely tired and fatigued and a bit depressed too. I have read on this forum that could be due to a COMT or CBS problem. I have tried to understand this by using this website; http://www.heartfixer.com/AMRI-Outcomes-Non-CV-Autism-Methyl Cycle.htm It gives a good explanation of it. However it is all a bit much too take in and I am not sure why I cannot tolerate methyl folate. What could be causing this? Due to my intolerance of thiols (sulphur) I have been on a low thiol diet since maybe two years ago. Reducing thiols made me feel a whole lot better. Only last week I introduced some cruciferous vegetable and tolerated them well. Normally this would of given me terrible headaches and fatigue. From what I have gathered from Andy Cutler thiols cause mercury to be redistributed around the body. Garlic and onions are still a no go, probably because they are very sulphury, these make me feel terrible still. Recently I also introduced Norival which contains P5P, something I couldn’t previously tolerate due to the fact it drives cysteine which I think was causing mercury distribution. Well now I can tolerate two caps (20mg P5P). This has improved my mood so much! I wonder if this ties into the COMT or CBS problem somehow? I decided to introduce this as aluminum blocks the enzyme necessary to recycle BH2 into BH4. It is still clear from the DMSA test that I am still dealing with aluminum. Seems to be working….. It seems to of increased my dopamine and serotonin. I feel happier and brighter.