My question is about all generic brands. I know quality of generics can vary from brand to brand, can the quality of the same generic brand change? I've been having a lot of health problems these last 3-4 months, but miraculously the one thing that has remained relatively stable is my mood. I've been taking Aurobindo Prozac/Fluoxetine 10 mg for at least 5 months and haven't had problems until recently. I've been taking a new bottle of Aurobindo Prozac for about 12 days. After about a week of taking the new bottle my mood began to drop rather quickly to the point where I'm very depressed now. I don't understand how this could happen since the new bottle was Aurobindo which was working great before. The exact same thing happened when I tried switching from Prozac to Paxil last month because the Paxil brand they gave me (Zydus) was a bad brand and taking it was essentially the same as taking no antidepressant. After I had been off the Prozac for 7-9 days my mood dropped rather drastically. Prozac has a very long half life which is why it took so long for it to clear my system. When I switched back to Prozac my mood improved again until recently. I guess I'll give it another week before I really start to worry, but I wanted to ask about this here first. Should I call the pharmacy about this? I have a feeling they're going to blow me off. I've been on various prescription antidepressants for the past 15 years so I know when a medication is working and when it isn't.