Hi all, I'm new here and I had a bad b12/folate experience, trying to make sense of where I went wrong. Background: Sensitive nervous system for 10 yrs, MCS, maybe chronic Lyme or related infection, probably leaky gut, long term adrenal fatigue & recent (Nov '13) adrenal burnout- In trying to heal adrenal problems, the first thing that actually helped was B12 & Folate (coenzymated); this made a tremendous difference for 2 weeks in my ability to do things (B12 1000mcg, Folate 1000 mcg), mood, sleep, energy, typing accuracy, and more. Then after 2 wks, I got manic anxiety, panic, photo sensitivity, it was so terrible & scary so I stopped it for a few days. I'm scared to restart, but my initial response indicates this is a necessary ingredient for me. I am able to work an easy full-time office job, so I don't want to be going crazy. Even if I wasn't working- I really don't ever want to get in such a bad way again. I could also tell that afterward it was an adrenal stress (lower back ache) so I need to keep it from getting so drastic. I didn't start this as an attempt at the Freddd Protocol. I just saw vague suggestions on adrenal fatigue blogs that said adding in the folate is important. I had been taking Methyl B12 & P5P for ages before this and never noticed much from them, so this implies I was/am folate deficient. I've been looking all over this site to find out what I should've done that would've controlled this response properly. Am I wrong- does the response sound like I shouldn't be near the folate? Some people suggest potassium (although I'm always told I need more magnesium and I thought they were antagonists?) and others say niacinamide (I took this after the overmethylation incident, but it didn't seem to do much of anything). I'm not ready to launch into a full scale methylation protocol because I want to use candida treatments, and increase zinc (lower copper) first. Doing them all at once would be way too much, and difficult to tell what's doing what. My diet is very limited in sugars/grains; I take a lot of alternating natural antibiotics (and probiotics) to control bacteria/possible lyme/parasites; haven't had the genetic methylation tests, but will. I am basically looking to establish a balanced and low key B vitamin regimen to keep me on track during a month of working on the gut health/minerals. I do take a liquid B complex but I'm not sure what to do with the additional B12/Folate, Pantothenic Acid dosages, etc. Not sure if I am generally an over or under methylator. I have in the past always had hangovers from very little alcohol. So probably regularly an under methylator, but the folate certainly had me over methylating. Questions: -I did have muscle cramps, but not severe. Would the potassium have helped control the anxiety/panic symptoms as well? I did not however have palpitations like many of you speak of. What are the forms/dosages of potassium that you guys are taking? Are food sources are not enough? -Why did my intolerance seem to build up over two weeks when I was steady with the dosage-not increasing? -In general what does the anxiety/overdrive response indicate? I know a lot of others experience more fatigue, headaches, etc. That was certainly not my experience although I did get a weird headache before I had that manic episode. -Where is Zinc in all of this? My plan is to probably try out LOWER dose folate (400mcg) on Mondays and Thursdays only so that I have some coming in, but I'm not going overboard. Once I go through my month with the Nystatin (for Candida), and Zinc increase then I will come back to focus on methylation (gently). Any insight is much appreciated; thank you for contributing to my healing!