I've been trying to incorporate Probiotics several times without any real success. As with everything, I know this is very individual. Something that doesn't work for you might work for someone else etc. But how can one distinguish whats really "die-off" which I personally feel being thrown out way too easy on the forums for all kind of side-effects, and whats not agreeing with your body? I've tried: Jarrow EPS > Ortho biotic > Renew life (Bfidio) > Align > Culturelle (currently ON) My side effects: I can take that you normally would have issues with your gut/bowel movements, some cramps etc. Apart from this, for every probiotic I'm experiencing depression which is creeping in to life along with general weakness, body aches, dizzyness etc. My cognitive functions is going downhill, impairing my focus/motivation and decision-making which is very notable at work. Today I found myself at some pretty bad brain fog/confusion when going shopping. I'm at day 6 of Culturelle brand (lactobacillus rhamnosus GG) which I've heard good things about, generally well-tolerated. But I'm figuring how long I can take this. As with the other probiotics, I eventually just quit because it was just too much. My background: Gut/IBS problems for long time with other physical/mental symptoms. I'm strongly thinking that I either have some bad bacteria or a systemic case of Candida. I've done a lot of herbal anti-biotics without taking probiotics for some months which I'm now trying to correct. Did a parasite cleanse just recently in hopes of making it easier to get my flora under control. I also started taking some prebiotics and will change my diet for the better. Before this Culturelle brand, I indulged in a Lot of sugars/junk food and stuff on the weekends which might explain a bit why I didn't progress. Anyone have an opinion on this, do I have to go through hell to feel better? I'm very determined on trying to push-through this time, just a bit cautious about possible harming myself even more.