After starting and stopping probiotics a couple of times I've come to find out that each time I started them again it would cause a depression. I had been taking probiotics without a problem for awhile, but then I stopped them for about 5 weeks or so. When I started taking them I started to get depressed. Then after stopping them the depression gradually lifted. Then I tried them again a few weeks later and the same thing happened. I was wondering if anyone has any theories. So far I have 2 theories. One is that it's due to some pathogen reacting with the probiotics. The other theory I've read is that probiotics can cause a Th2 immune response if a person is Th2 dominant (or Th1 if the person is Th1 dominant). There are certain Th1 and Th2 cytokines that can induce depression. I've also read that candida can cause a shift to Th2 dominance so it could be a combination of the two theories, but I'd like to hear of any alternate theories and strategies because I don't think it's a good idea to abstain from probiotics indefinitely. Right now I'm taking various supplements such as garlic, olive leaf extract, oregano oil, spilanthes, and noni juice to kill off any pathogen. And I'm taking inosine and a few other supplements to shift from Th2 to Th1, but also some supplements listed as Th2 that inhibit inflammatory cytokines to make sure my immune system doesn't go crazy.