I have mentioned on PR somewhere b4 that I am on about 30-45mg of Deplin a day. This has taken care of my chronic fatigue and depression but this is not all that there is to my CFS. I still suffer from an easily over reactive immune system that likes to attack myself, a liver phase 1 detox that is way too fast and a slow liver phase 2. That pretty much sums up CFS for most people if you exclude the gut As you imagine taking Deplin 3-4 times a day is Not cheap so you can imagine my surprise when I went back on my fall/winter regime that I realize that I can completely do without the Deplin supplements. I started making yogurt at home again with my specific strains. Not only it is very anti inflammatory to the gut it has eliminated my need for Deplin. On further research I found out that certain probiotic strains, besides synthesizing the B vitamins, specifically synthesize the active forms of them. Im talking about methylfolate and methylcobalamin. In fact from all that I have read the only B vitamin that might not be synthesized in the gut is B6 and even that is because of lack of research. This might be a cheaper alternative for some of you out there instead of Deplin. To try out if this works for you take Danon's Activia or Jarrow EPS and see how you feel. It has to be this specific brand of probiotics and not the others.