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Prevalence of Irritable Bowel Syndrome and Chronic Fatigue 10 Years after Giardia Infection.

Discussion in 'Latest ME/CFS Research' started by Murph, Jan 31, 2018.

  1. Murph

    Murph :)

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    Clin Gastroenterol Hepatol. 2018 Jan 25. pii: S1542-3565(18)30088-0. doi: 10.1016/j.cgh.2018.01.022. [Epub ahead of print]
    Prevalence of Irritable Bowel Syndrome and Chronic Fatigue 10 Years after Giardia Infection.
    Litleskare S1, Rortveit G2, Eide GE3, Hanevik K4, Langeland N4, Wensaas KA2.
    Author information
    Abstract

    BACKGROUND & AIMS:
    Irritable bowel syndrome (IBS) is a complication that can follow gastrointestinal infection, but it is not clear if patients also develop chronic fatigue. We investigated the prevalence and odds ratio of IBS and chronic fatigue 10 years after an outbreak of Giardia lamblia, compared with a control cohort, and changes in prevalence over time.

    METHODS:
    We performed a prospective follow-up study of 1252 laboratory-confirmed cases of giardiasis (exposed), which developed in Bergen, Norway in 2004. Statistics Norway provided us with information from 2504 unexposed individuals from Bergen, matched by age and sex (controls). Questionnaires were mailed to participants 3, 6, and 10 years after the outbreak. Results from the 3- and 6-year follow-up analyses have been published previously. We report the 10-year data and changes in prevalence among time points, determined by logistic regression using generalized estimating equations.

    RESULTS:
    The prevalence of IBS 10 years after the outbreak was 43% (n=248) among 576 exposed individuals and 14% (n=94) among 685 controls (adjusted odds ratio for development of IBS in exposed individuals, 4.74; 95% CI, 3.61-6.23). At this time point, the prevalence of chronic fatigue was 26% (n=153) among 587 exposed individuals and 11% (n=73) among 692 controls (adjusted odds ratio, 3.01; 95% CI, 2.22-4.08). The prevalence of IBS among exposed persons did not change significantly from 6 years after infection (40%) to 10 years after infection (43%; adjusted odds ratio for the change 1.03; 95% CI, 0.87-1.22). However, the prevalence of chronic fatigue decreased from 31% at 6 years after infection to 26% at 10 years after infection (adjusted odds ratio for the change 0.74; 95% CI, 0.61-0.90).

    CONCLUSION:
    The prevalence of IBS did not change significantly from 6 years after an outbreak of Giardia lamblia infection in Norway to 10 years after. However, the prevalence of chronic fatigue decreased significantly from 6 to 10 years afterward. IBS and chronic fatigue were still associated with giardiasis 10 years after the outbreak.

    Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

    KEYWORDS:
    bacteria; epidemiology; long-term outcome; microbiota

    PMID:
    29378314
    DOI:
    10.1016/j.cgh.2018.01.022
     
  2. Murph

    Murph :)

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    Not all this "chronic fatigue" will be me/cfs. Not all of it won't be either... We all know infection starts it but huge prospective studies like this are important for codifying that knowledge.
     
    Dolphin and Runner5 like this.

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