I am homozygous for a1298c mutation and negative (normal) for the c677T mutation in the mthfr gene. I am waiting for 23andme to come back and I am just trying to do my homework and get whatever other testing that I need to get done done. I have had a ton - 30 plus pages - of bloodwork (including neurotransmitters and precursors) done last year. I am relatively health (no CFS or anything) other than my anxiety / depression / ocd. My dr had me taking 1000 mg shots of methylcobalamin. A psychiatrist gave me 15mg of Deplin. I later learned that I had MTHFR mutations. I am doing a phone consult with my dr this Thursday (weather pending) and will be asking him for a rx for bloodwork. I am going to ask for: b12 C (absorbic acid was off the charts low on fall tests. haven't been supplementing) B6 (was very high in fall due to supplementing) magnesium copper cortisol rbc folate (high due to supplementing with folic acid all spring and summer under drs order) What other tests should I have done so that I can "hit the ground running" when 23andme comes back? Some people have suggested getting hair metal tests done. I did get thousands of dollars in testing done last year. I would like to try and not get anything unnecessary as I spent 5k in medical out of pocket last year. At the same time, if I need something, I'd like to get it. I do live in NY which complicates things (lots of stuff isn't available in NYS). Other people have mentioned lithium testing. Is that essential? Can a regular doctor give me an rx for that? Or is that lithium test different? I did talk to integrative psychiatry, but they couldn't tell me if their test tested lithium. I assume testing for metals is so that I can find that stuff out? I did have aluminum show up in a blood test in the fall. My rbc folate was high in fall (due to supplementing with folic acid?) I have heard about this possibly contributing to cancer. Is there a way to lower this level? Does it naturally go down? My gut "seems" to be in good shape. Testing showed no yeast, no celiac, no major food allergies. I have read in numerous places that the gut should be healed first before addressing MTHFR. One thing I want to mention is that I have horrible health anxiety. I have done sooo much research and have had soooo much testing done that I want things as simple as possible. It seems that whenever I post a question that people suggest 50 more things that I need to do. I would like to keep it to the simple and imperative. Last question: If I DO have a COMT, what difference does that make in the course of action? Thank you in advance!