Hello, all. I have had standard ME symptoms for the last twenty years, plus mental problems (I know these actually are common ME symptoms, but the doctors don't). In 2014 I tried to kill myself and a psychiatrist, who knew nothing about ME, prescribed pregabalin (Lyrica) for anxiety. It wrought an incredible improvement in almost all my symptoms, mental and physical, though it had some troublesome side effects. I had a life for the first time in decades and could e.g. go swimming and play the piano. (My NHS doctors had no idea why this was happening and just said, "Carry on taking it since it seems to be doing you good.") Sadly its effects slowly started to fade, and in October they went away with a bang. Since then I have been experiencing a slow slide back into my previous level of functioning, or rather nonfunctioning. I do not want to lose the life I'd managed to build. I am pondering some very important questions: 1. Why did pregabalin cause remission? (I know it is GABAergic and a calcium channel modulator. I also know Dr Jay Goldstein used it, or rather gabapentin, in his list of drugs that can cause quick remission. I still don't quite understand how it worked, though.) 2. Why did it stop working, other than because all/most drugs stop working for ME patients after a while? 3. Can it be made to work again? (I heard theanine might help with this, but have tried it and seen no improvement.) 4. If not, can a different drug do the same thing? 5. Since it is not having much effect, should I stop taking it? (I take 400mg daily in two divided doses. The most I have taken is 600mg, which is the normal maximum dose recommended by non-ME doctors. I suppose I could even consider taking more, but then I would have to go on increasing the dose to infinity! This is mostly an academic question anyway as I feel terrible every time I try to reduce the dose of pregabalin, so do not think I could bring myself to do it. I feel very bad all the time already.) I hope it was all right to start a new thread. I see there are old threads about pregabalin but wasn't sure it was OK to resurrect them.