My doc gave me prednisone to take (20mg/day in the mornin) and it works amazingly well. I know prednisone has some serious side effects and since I have lyme, I am scared to take it daily. I have only taken it once. I have heard pregnenolone is also good for addressing autoimmune conditions in doses of 100-200 mg per day. Does anyone have experience with it? Anything else I might consider for severe autoimmune / intolerance issues.