I am probably going to start a high dose (40mg) of this tomorrow, gradually tapering off 5mg a week over the next 8 weeks. I am not taking it for ME/CFS, I am taking it to try and get my ulcerative colitis into remission, but I am very concerned about the impact on my ME/CFS along with the Bartonella infection I was diagnosed with and have been treating for the last 8 months. My limited understanding is that this will suppress my immune system and cortisol production and at first I may feel pretty good, but ultimately it might allow the Bartonella and any other undiagnosed pathogen I may have linked with ME/CFS to proliferate while I am on it. I just don't know what else to do. The UC is not getting better on the mesalazine treatment I have been taking and I continue to lose weight - I've already lost more than 40lbs over the last few months and my gastro wants to halt that decline and believes the steroid is likely to knock me into remission. In terms of alternative treatments, I could have other even harsher immunomodulatory drugs, such as monoclonal antibodies against TNF-a or have my colon removed. None of these seem like better options really. I am hoping someone else here will have taken prednisolone at this sort of dose while having ME/CFS and can tell me what to expect?