Hi, this question came up here quite often. Why do probiotics cause problems for many PWCs? There are not many studies about it and most of them are of no value for us. I'm convinced that we should take matters into our own hands as good as we can, as long as there is no alternative. Therefore I would like to conduct some practical "tests" and observe their results in order to shed more light into the mechanism behind the problems. Why wait for others to do studies for you when we can find out at least something by ourselves? Please feel free to participate. Test 1: Take your probiotic after you get up in the morning but don't eat anything for the next 3-4 hours/till lunch. For me it seems that when I take probiotics shortly after I get up and don't eat anything for the next 3-4 hours, I seem to tolerate it better. However if I take them before a meal or during the day they cause great flareups. Maybe the adverse reactions can only be caused by probiotic + food, where the food gets metabolized in the wrong way. It would be awesome if others could tell me their observations. Do you get adverse reactions to probiotics when you take them after you get up and don't eat anything afterwards for some hours OR do you tolerate them better now? If you need your breakfast or food within 3-4 hours after you get up, please do not take part in the test. The basic aim: We try to find out if it is the probiotic that causes the problem OR if it is a byproduct. I started the test today [I took the same probiotic to lunch yesterday and got a huge flareup afterwards, right now it's 2 hours after I took it and I'm fine. EDIT: 3 hours later I start to feel slightly unwell EDIT2: 4-5 hours later I feel very good].