Thanks for all that info. Its very helpful to me. I wish a doctor would test my STANDING norephinephrine levels!! I only currently have abnormally high 24hr urine ones. I'll report your post to bring your question to the mods so they can advise. (I had the first issue happening at one point back when the site changed servers it then came good for me) I havent found a doctor yet to give me saline scripts.. thou did found a doctor who does a once per week IV clinic early mornings who would be willing to allow me to have saline IVs there.. unfortunately thou its the other side of the city and I cant drive. Im about to thou try yet another doctor and hopefully will have some help there. I hhope the Mestonin works for you. I havent heard of that drug before. Cardio rehab? Im not sure how one would do that with ME/CFS..best luck. It may be great for those who just have dysautonomia..but I doubt if cardio stuff would be good for ME people (it can also triger mast cell issues if someone has them).