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POTS Associated with Significant Symptoms & Impairment -- BMJ article & pop press response

Discussion in 'Latest ME/CFS Research' started by Firestormm, Jun 16, 2014.

  1. Ecoclimber

    Ecoclimber Senior Member

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    Mercer Island Wa
    Didn't know quite where to post this but since this thread is related to Postural Tachycardia Syndrome, I put it in here

    Front. Neurol. | doi: 10.3389/fneur.2014.00118
    Sleep disturbances and autonomic dysfunction in patients with postural orthostatic tachycardia syndrome
    Julia Mallien2, Stefan Isenmann2, Anne Mrazek2 and Carl-Albrecht Haensch1*
    • 1Department of Neurology, Maria Hilf Kliniken Mönchengladbach, Germany
    • 2Department of Neurology, HELIOS Klinkum Wuppertal, University of Witten/Herdecke, Germany
    Many patients with Postural Tachycardia Syndrome (PoTS) suffer from fatigue, daytime sleepiness and sleeping disturbances.

    The objective of this study was to compare subjective and objective sleep quality of PoTS patients with a group of healthy controls.

    All Patients completed a Pittsburgh Sleep Quality Index questionnaire and the Epworth Sleepiness Scale. The patients sleep architecture, heart rate and heart rate variability measurements were taken during one night at the sleep laboratorium. All Data was collected at the Sleep Unit, at Helios Klinikum Wuppertal. 38 patients diagnosed with PoTS were compared to 31 healthy controls, matched in age and gender.

    Patients with PoTS reached significantly higher scores in sleep questionnaires, which means that they were more sleepy and had a lower sleep qualitiy. Polysomnography showed a significantly higher proportion of stage 2 sleep.

    The results of heart rate variability analysis in different sleep stages confirmed changes in autonomic activity in both groups. PoTS patients, however, showed a diminished variability of the LF band, HF band and LF/HF ratio in different sleep stages.

    It can therefore be gathererd that PoTS could be considered as potential differential diagnosis for sleep disturbances since PoTS patients had a subjective diminished sleep quality, reached higher levels of daytime sleepiness and showed a higher proportion of stage 2 sleep. PoTS patients showed furthermore a reduction of LF/HF ratio variability in different sleep stages.

     
  2. Leopardtail

    Leopardtail Senior Member

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    full article online: http://www.telegraph.co.uk/science/...-one-third-of-patients-wrongly-diagnosed.html
     
  3. Griffin

    Griffin

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    I'm not sure what this actually adds to the original Telegraph article on 17 June. Am I missing something?

    Incidentally my POTS is only partially resolved by treatment - I still have tachycardia (though lower than untreated) and my BP is abnormally low, dizzy on standing still, etc. It's just not quite so bad. I don't think it's as easy as saying POTS is treatable in all cases.
     
  4. Leopardtail

    Leopardtail Senior Member

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    The first link posted in the thread only showed partial information, that link goes straight to the full article.
    You will probably want to read the Julia Newton study when it publishes. It discusses various approaches to POTS/OI and who they are suitable for.
     
    kevinj likes this.
  5. kevinj

    kevinj

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    What is the test for Potts please? Is it a blood test; can my doctor do it?
     
  6. Leopardtail

    Leopardtail Senior Member

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    The simplest test (your doctor could do it, but is more likely to refer you) is to take your blood pressure and pulse while lying down, then ask you to sit up rapidly and repeat. The manner in which it varies will give a 'first clue' as to whether you might have OI, POTS or NMH (different forms of a similar problem).
     
    kevinj likes this.
  7. ahimsa

    ahimsa Senior Member

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    Getting these tests done in the doctor's office is good advice. It can provide a "first clue" as @Leopardtail says.

    But just to add a bit more information for @kevinj and others who are brand new to POTS and NMH, there are some patients (I think mostly NMH patients) who have normal results in the doctor's office but have abnormal results on a tilt table test.

    So, the doctor also needs to take the patient's history since that can be just as important a clue as the testing. That is, does the patient have symptoms that sound like Orthostatic Intolerance?

    There are many symptom lists but here's a link to one - http://emedicine.medscape.com/article/902155-overview#aw2aab6b3 (scroll to the bottom of this section to see list of symptoms)
     
    Leopardtail and kevinj like this.
  8. lookinglass

    lookinglass

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    Sasha

    8 years ago in February my husband took me to Jamaica where we stayed for a month in a charming north coast small Aparthotel. The receptionist took us to view the poolside apartment which had its windows curtained when I entered the room, followed by my husband.

    I took one breath and almost choked. I could not breathe and had to rush from the room. I do have slight asthma and a night cough so I assumed it was this that was reacting with the very powerful bug spray which the receptionist admitted had been liberally used and recently. We said if the room was aired properly we would take it.

    A month later on arriving back home in Spain I began to feel odd. My feet were heavy, I couldn't walk easily. I had a mild fever and night sweats and thought I may be coming down with flue. In April I still felt unwell and then came down with a very bad bronchial infection that required antibiotics. One day in May, at dinner in a restaurant, I became suddenly very unwell. Nausea, incredibly weak and heavy, could not walk and had to be almost carried to our car to go home. At home I began to shiver as if I had Malaria and was freezing cold. After 2 days I made the first of many future visits to my brilliant holistic GP who was English, in order to eliminate with blood, ecg tests urine etc. Palpitations were soon a frightening daily occurrence along with vomiting frequently, diarrhea and an inability to eat or keep anything down. I needed to rest and sleep and could barely walk. After a month of negative test results and ecg's he diagnosed me with M.E. Later bad attacks resulted in near fainting fits and POTS was also diagnosed. It took two years of daily vitamin and magnesium injections before I felt IT was sightly losing its grip. This week I had a POTS attack and ended up in two Spanish Hospitals in Tenerife where we now live. Out of 6 doctors who consulted me after brain scans and more xrays and blood tests they allowed me home with 6 stitches in a bad facial cut from my fall on to hard unforgiving tiles. Not one of these doctors had ever heard of M.E. even though I spelt it out for them. They knew about CFS but only vaguely. They thought as I am now 74 that I may have had a stroke but the scan proved clear.

    My M.E. has not completely gone for good. And I am convinced it never will. I still get my bad days, and my good days. But I am also convinced of what you say. That POTS is all just a part of the whole. In my case I cannot help thinking...was it that horrendous bug killer spray that poisoned my system and lowered my whole immune system also.
     
    Last edited: Sep 5, 2014
  9. Sasha

    Sasha Fine, thank you

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    Really sorry to hear about your awful experiences, @lookinglass. Must make it even harder to be somewhere where MR isn't really on the radar.
     

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