The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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Potential Suramin Alternatives - Sytrinol and Kudzu (Anti Purinergic Therapy)

Discussion in 'General Treatment' started by Jesse2233, Jun 23, 2017.

  1. Hip

    Hip Senior Member

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    Looks like Lapodin contains emodin, and we found earlier that transdermal emodin (at least in the form of Liu He Dan ointment) will not be effective.
     
  2. debored13

    debored13 Senior Member

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    Does the solvent matter in this case, at all?
     
  3. Hip

    Hip Senior Member

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    It might do, and the concentration of emodin in the Lapodin would also be a major factor. Without a pharmacokinetic study of Lapodin, though, it would hard to know what blood levels of emodin Lapodin will achieve. The problem with emodin is its toxicity, which means you should not really use it for more than two weeks in a row (even when using normal safe doses).
     
    debored13 likes this.
  4. debored13

    debored13 Senior Member

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    I guess it's impossible to know without studies, but I have a feeling that this would be more bioavailable than the aforementioned ointment. Considering testing it out but since emodin is known to lower cortisol and I have super low cortisol idk if its a good idea.
     
  5. Hip

    Hip Senior Member

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    Three days ago I took 200 mg of the Brilliant Blue FCF food dye powder that I bought. I took it in two divided doses of 100 mg, dissolved in 200 ml of water. The first 100 mg I took at 2 pm in the afternoon, and the next 100 mg I took at 6 pm.

    There were no noticeable effects from the first 100 mg in the hours immediately after taking it, but a couple of hours after the second 100 mg, I noticed I started to feel angry and irritable (which are symptoms that I have experienced as side effects from several supplements in the past). This anger side effect lasted for around 24 hours.

    The next day I noticed that my stool was an intense deep green color, which looked rather odd. So obviously 200 mg is quite a high dose, as you would not normally expect a food dye used in the food or drink you consume to color your stools in this way.

    In the next few days after this single 200 mg dose I found that my IBS-D symptoms were noticeably worsened, so I guess the Brilliant Blue FCF may be mildly irritating to the gut (although my intestines are pretty sensitive, because even spicy food will greatly worsen my IBS-D).

    I did not notice any improvements in ME/CFS symptoms from the Brilliant Blue FCF, although I only took that one dose.

    Because Brilliant Blue FCF seems to worsen my IBS-D (which then makes me feel generally worse) and causes these anger and irritability side effects, I am not going to take it again in these high doses, but I may at some point experiment with much lower doses, eg 20 mg daily.
     
    Last edited: Dec 4, 2017
    garcia, nandixon, melihtas and 3 others like this.
  6. melihtas

    melihtas Senior Member

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    Istanbul Turkey
    ErdemX and Hip like this.
  7. debored13

    debored13 Senior Member

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    has anyone experimented with sytrinol or emodin yet, besides matt?
     
  8. debored13

    debored13 Senior Member

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    i'm quite happy to experiment with emodin but am going to wait until my endocrinologist visit
     

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