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Postural orthostatic tachycardia syndrome is associated with platelet storage pool deficiency

Discussion in 'Other Health News and Research' started by Kyla, Sep 16, 2016.

  1. Kyla

    Kyla ᴀɴɴɪᴇ ɢꜱᴀᴍᴩᴇʟ

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    http://journals.lww.com/md-journal/...l_orthostatic_tachycardia_syndrome_is.46.aspx
    (Open access)


     
    taniaaust1, J.G, L'engle and 8 others like this.
  2. Sidereal

    Sidereal Senior Member

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    Definitely fits me.

    Interesting.
     
    L'engle, erin and JaimeS like this.
  3. Justin30

    Justin30 Senior Member

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    By 5HT are they refering to the precursor to seratonin?

    I mean like 5HTP?

    Would be nice to know if we are not getting this from our food amd therefore showcase a malabsorbtion of mito process not working.
     
    L'engle likes this.
  4. adreno

    adreno PR activist

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    5-HT is short for serotonin.
     
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  5. Justin30

    Justin30 Senior Member

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    Thank you I thought was something like that.
     
    L'engle likes this.
  6. JaimeS

    JaimeS Senior Member

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    Definitely -- and this might further link to EDS. In some, this might be why the increased bleeding tendency occurs.

    -J
     
    L'engle likes this.
  7. adreno

    adreno PR activist

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    No increased bleeding here. An SSRI seems to help - somewhat. Too much serotonin OTOH makes OI worse (I'm on half the regular dose).
     
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  8. wastwater

    wastwater Senior Member

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    I have low platelets but none of these symptoms mentioned
     
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  9. L'engle

    L'engle moogle

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    I've gotten low platelets from various supplements and foods so I would guess baseline is in the low end of normal. Spleen ultrasound was normal.

    I have little dots of blood under the skin on my upper arms most of the time. (petechia?)
     
  10. bel canto

    bel canto Senior Member

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    A well-respected hematologist recently told me that SSRI's can lead to an acquired bleeding disorder. As a POTS patient, I've never associated a mild bleeding disorder with that condition. Very interesting.
     
  11. bertiedog

    bertiedog Senior Member

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    Fits me too.

    Pam
     
  12. bertiedog

    bertiedog Senior Member

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    I do well with sumatriptan (Immigran) which constricts the blood vessels in order to control my almost daily migraines and I believe there is a serotonin connection here but not sure what that is without looking it up.

    Pam
     
  13. taniaaust1

    taniaaust1 Senior Member

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    oh no, I bet I have this too. I have a history of abnormal bleeding though my blood also clots faster then its supposed to do due to having a double copy of the MTHFR mutation so I seem to have two different conflicting problems with both a bleeding abnormality and a higher clotting abnormality which shows up on clotting tests.

    I had terrible nosebleeds as a child to the point a dr for some strange reason decided to take my tonsils out due to the nose bleeds as he thought that would help (strangely that did seem to help some and I stopped getting the almost daily nose bleeds).

    Then I haemorraged during the tonsil removal surgery and needed blood transfusions as they couldnt stop me from bleeding from the surgery. (I also get very heavy periods and my daughter gets severe nose bleeds too and my mother almost bled to death after childbirth and needed blood transfusions).
     
  14. taniaaust1

    taniaaust1 Senior Member

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    I just have looked up more info on this


    http://www.wfh.org/en/page.aspx?pid=655
     

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