There was a great thread on here about SOD2. There was a member who got significant energy from taking Biotec Extra Energy Enzymes, as in being able to get out of bed. I don't understand the mechanism yet; haven't gotten that far in my research. It's on my list of stuff to try after I get a good handle on methylation. For now, I'm viewing SOD2 as "icing on the cake", not the the main thing causing fatigue, as 99% of the people on here have MTHFR, and far fewer have SOD mutations. But I believe it would explain for me why back when I was normal, why I never had quite the energy of other people, needed more sleep than others, etc. But getting somebody out of bed is a lot more than "icing", so you never know.