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Post your NutrEval Krebs Cycle Results...

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by dannybex, May 12, 2013.

  1. caledonia

    caledonia

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    There was a great thread on here about SOD2. There was a member who got significant energy from taking Biotec Extra Energy Enzymes, as in being able to get out of bed. I don't understand the mechanism yet; haven't gotten that far in my research. It's on my list of stuff to try after I get a good handle on methylation.

    For now, I'm viewing SOD2 as "icing on the cake", not the the main thing causing fatigue, as 99% of the people on here have MTHFR, and far fewer have SOD mutations. But I believe it would explain for me why back when I was normal, why I never had quite the energy of other people, needed more sleep than others, etc.

    But getting somebody out of bed is a lot more than "icing", so you never know.
    roxie60 likes this.
  2. dannybex

    dannybex Senior Member

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    Wow. And you survived! :)

    Did you notice any worsening during those six months? And if I may ask, how many fillings did you have?
  3. caledonia

    caledonia

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    I know, I'm surprised I was able to tolerate it all, knowing what I know now about the shape of my methylation cycle.

    I don't remember feeling worse, other than if I got the dose too high. Then I would feel flu like aches and extra tired. So I just cut back until I felt ok. I think I had 6 fillings at that time. Most of them on the small side.
  4. gregh286

    gregh286

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    Hi guys,
    hope someone can help me with krebs cycle.(attached to post)
    just got results last week. On/off fatigue last 12 months,
    I get intermittent fatigue, with good respites of 7-10 days, so my system is "on the fence",
    This looks about right with my krebs cycle as most acids, etc are right on the low border, succinic acid is non-existant.

    I would really really appreciate any comments or advice to improve my cycle and stabilise my energy with supplement.
    The lactic acid is really low @ 2.0, but i eat much meat, I would have expected this protein score to be higher.

    Thanks guys
    Greg

    Attached Files:

  5. dannybex

    dannybex Senior Member

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    A year and a half later, I think I finally figured out another piece of the puzzle.

    I've long suspected that I had and still have a huge issue with salicylates/phenols. Every time I try to eat like a 'normal person', I'll experience much, much worse symptoms in the following days.

    And sure enough, what else (besides heavy metals, lack of cofactors) causes an inhbition at a-ketoglutaric acid?Salicylates.

    Several studies note this, but here's a simple chart showing it:http://www.derangedphysiology.com/p...idosis/lactic-acidosis-due-to-salycylates.php

    And here's one study that mentions sals and kreb's cycle inhibition:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651525/"It is shown that inhibition in succinate dehydrogenase and α-ketoglutarate dehydrogenase by salicylate contributes substantially to the cumulative inhibition of the Krebs cycle by salicylates."

    And as Caledonia says above, and Rich Van K told me years ago, that if this is blocked, then that means that the branched-chain amino acids will not be fed into the krebs cycle, so if the inhibition is strong enough, then one ends up using one's own muscle for "fuel". One's muscle will be catabolized resulting in significant muscle loss, which is exactly what has happened in my case, especially in my lower legs and feet. When I can walk, I feel like I'm walking on glass, as I've lost so much muscle.


    Hoping it's not too late to turn this around.
  6. gregh286

    gregh286

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    h dannybex,
    My krebs is similar to yours. How do you propose to address the problems.
    Thanks.
  7. caledonia

    caledonia

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    Hi greg,
    If you want Dannybex to get an alert, then put an "at sign" in front of his name. So like this @dannybex .

    I also had a drop at succinic acid and was doing vitamin E succinate (Dry E) to support it for awhile. If you can determine that salicylates are a problem, then you would want to avoid those.

    Then, of course, supplement with any co-factors. The metals will automatically be detoxed via killing off any bad gut bugs, and doing methylation treatment.

    As I've proceeded further with methylation, I no longer need to supplement with the vitamin E (as determined by muscle testing). I have all my mercury out, but am still detoxing lead and several other minor metals.
  8. caledonia

    caledonia

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    If you haven't already done so, you can interpret your results with the Nutreval Interpretation Guide in my signature links below. Use the tally sheet at the end to summarize what supplements to take, what metals need to be detoxed, if you need to work further on your gut and so on.
  9. gregh286

    gregh286

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    Thanks caledonia for that help.
    Its appreciated.
  10. dannybex

    dannybex Senior Member

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    Hi Greg,

    I'm quite sure yet, but am looking into several options -- will post more as soon as I have a coherent (or at least semi-coherent!) plan. It's very complicated, and an 'expert' told me the other day that once one has a salicylate intolerance, then they have it for life (like lactose intolerance) -- but I'm not sure if that's true.

    Wow -- just took a look at your krebs cycle, and man, it's almost identical to mine. You're fortunate to be figuring this out so early, compared to most of the rest of us. Where's a time machine when you need one??


    Thanks @caledonia for your input -- very much appreciated. :)

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